指压疗法与帕瑞昔布钠治疗急性肾绞痛的前瞻性队列研究

Acupressure versus parecoxib sodium in acute renal colic: A prospective cohort study.

作者信息

Chen Chiwei, Zhang Zhenpeng, Lin Mandi, Wang Zhigang, Liu Hao, Meng Hao, Wang Jun, Chen Ming, Xiang Songtao, Qiu Yunqiao, Liu Hong

机构信息

The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

出版信息

Front Med (Lausanne). 2023 Jan 9;9:968433. doi: 10.3389/fmed.2022.968433. eCollection 2022.

DOI:10.3389/fmed.2022.968433

PMID:36698807

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9868725/

Abstract

BACKGROUND

Here provides a complementary treatment, acupressure at the Qiu acupoint, a novel acupoint, which potentially alleviates renal colic.

MATERIALS AND METHODS

90 patients were included in this study. Acupressure-group patients ( = 46) were administered acupressure at the Qiu acupoint following a preset protocol. Parecoxib sodium-group patients ( = 44) were administered parecoxib sodium (40 mg) ( the direct intravenous route). The visual analog scale (VAS) was used to evaluate pain intensity at baseline and at 1, 5, 10, 20, 30, and 120 min after initiating the intervention. Linear mixed effects model was performed to detect the rate of decrease of VAS per time and their covariant effect on the efficacy of acupressure.

RESULTS

No significant statistical differences in baseline data and VAS scores were observed. The acupressure group obtained lower VAS scores at the 1st, 5th, 10th, and 20th minute than the parecoxib sodium group after initiating the intervention (mean: 4.33 vs. 7.61, mean difference (MD): 3.29, 95% CI: 0.23, 2.84; mean: 2.65 vs. 7.61, MD: 4.96, 95% CI: 4.44, 5.49; mean: 1.63 vs. 6.59, MD: 4.96, 95% CI: 4.48, 5.44; mean: 1.26 vs. 3.64 MD: 2.38, 95% CI: 1.87, 2.88; < 0.05). The markedly effective rate was similar between the two groups. The linear mixed effects model demonstrated that acupressure at the Qiu point was significantly faster than parecoxib sodium in decreasing VAS scores with an estimate of -2.05 (95% CI: -2.51, -1.59, = 0.000), especially within 10 minutes with an estimate of 0.18 (95% CI: 0.12, 0.25, = 0.000).

CONCLUSION

Acupressure at the Qiu acupoint is significantly faster than parecoxib sodium in decreasing VAS scores within 10 minutes.

CLINICAL TRIAL REGISTRATION

http://www.chictr.org.cn/, identifier 2100047168.

摘要

背景

本文提供了一种辅助治疗方法，即对一个新穴位——丘墟穴进行指压，该方法可能缓解肾绞痛。

材料与方法

本研究纳入90例患者。指压组患者（n = 46）按照预设方案对丘墟穴进行指压。帕瑞昔布钠组患者（n = 44）静脉注射帕瑞昔布钠（40 mg）。采用视觉模拟评分法（VAS）在基线以及干预开始后1、5、10、20、30和120分钟评估疼痛强度。采用线性混合效应模型检测VAS评分随时间的下降速率及其对指压疗效的协变量效应。

结果

两组患者的基线数据和VAS评分无显著统计学差异。干预开始后，指压组在第1、5、10和20分钟时的VAS评分低于帕瑞昔布钠组（均值：4.33对7.61，平均差值（MD）：3.29，95%可信区间（CI）：0.23，2.84；均值：2.65对7.61，MD：4.96，95% CI：4.44，5.49；均值：1.63对6.59，MD：4.96，95% CI：4.48，5.44；均值：1.26对3.64，MD：2.38，95% CI：1.87，2.88；P < 0.05）。两组的显效率相似。线性混合效应模型表明，丘墟穴指压在降低VAS评分方面明显快于帕瑞昔布钠，估计值为 -2.05（95% CI：-2.51，-1.59，P = 0.000），尤其是在10分钟内，估计值为0.18（95% CI：0.12，0.25，P = 0.000）。