Calatroni Marta, Moroni Gabriella, Ponticelli Claudio
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Nephrology and Dialysis Division, IRCCS Humanitas Research Hospital, Milan, Italy.
Front Med (Lausanne). 2023 Jan 9;9:990252. doi: 10.3389/fmed.2022.990252. eCollection 2022.
Sarcoidosis is a systemic inflammatory disease of unknown etiology. Kidney involvement in sarcoidosis may be present in up 25-30% of cases. An early diagnosis and prompt treatment with corticosteroids can improve the prognosis but rarely renal sarcoidosis can lead to kidney failure needing renal replacement therapy (RRT). Acute kidney injury (AKI) in sarcoidosis may be caused by granulomatous interstitial nephritis (GIN) or hypercalcemia. These disorders are usually clinically silent and may lead end stage renal disease (ESKD) if not diagnosed or detected too late. In patients with ESKD, dialysis and renal transplantation can offer results comparable to those observed in patients with other causes of kidney failure. Based on a review of literature, we present an overview of RRT in patients with AKI or chronic kidney disease (CKD) caused by sarcoidosis.
结节病是一种病因不明的全身性炎症性疾病。结节病累及肾脏的情况在25%至30%的病例中可能存在。早期诊断并及时使用糖皮质激素治疗可改善预后,但肾结节病很少会导致肾衰竭而需要肾脏替代治疗(RRT)。结节病中的急性肾损伤(AKI)可能由肉芽肿性间质性肾炎(GIN)或高钙血症引起。这些病症通常在临床上没有症状,如果未被诊断或发现过晚,可能会导致终末期肾病(ESKD)。对于ESKD患者,透析和肾移植的效果与其他肾衰竭病因患者的情况相当。基于文献综述,我们概述了结节病所致AKI或慢性肾脏病(CKD)患者的肾脏替代治疗。