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肠道微生物群及基于微生物群的感染治疗方法。

Gut microbiota and microbiota-based therapies for infection.

作者信息

Chopra Teena, Hecht Gail, Tillotson Glenn

机构信息

Division of Infectious Diseases, Wayne State University, Detroit, MI, United States.

Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, IL, United States.

出版信息

Front Med (Lausanne). 2023 Jan 9;9:1093329. doi: 10.3389/fmed.2022.1093329. eCollection 2022.

Abstract

infection poses significant clinical challenges due to its recurrent nature. Current antibiotic management does not address the underlying issue, that of a disturbed gastrointestinal microbiome, called dysbiosis. This provides a supportive environment for the germination of spores which lead to infection and toxin production as well as an array of other health conditions. The use of microbiome restoration therapies such as live biotherapeutics can reverse dysbiosis and lead to good clinical outcomes. Several such therapies are under clinical investigation.

摘要

由于感染具有复发性,它带来了重大的临床挑战。目前的抗生素治疗并未解决根本问题,即胃肠道微生物群紊乱,也就是生态失调。这为孢子萌发提供了有利环境,而孢子会导致感染、毒素产生以及一系列其他健康问题。使用微生物群恢复疗法,如活体生物治疗药物,可以扭转生态失调并带来良好的临床效果。有几种这样的疗法正在进行临床研究。

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