Song Yujiao, Yin Defei, Zhang Zhenyi, Chi Lili
Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Digestive System Department II, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Front Pharmacol. 2023 Jan 9;13:1089231. doi: 10.3389/fphar.2022.1089231. eCollection 2022.
Functional dyspepsia (FD) is the most common clinical gastrointestinal disease, with complex and prolonged clinical symptoms. The prevalence of FD is increasing year by year, seriously affecting the quality of life of patients. The main causes of FD are related to abnormal gastrointestinal dynamics, increased visceral sensitivity, (HP) infection, intestinal flora disturbance and psychological factors. A review of the relevant literature reveals that the mechanisms of traditional Chinese medicine (TCM) in the treatment of FD mainly involve the following pathways:5-HT signal pathway, AMPK signal pathway,C-kit signal pathway, CRF signal pathway, PERK signal pathway,NF-κB signal pathway. Based on a holistic concept, TCM promotes gastrointestinal motility, regulates visceral sensitivity and alleviates gastrointestinal inflammation through multiple signal pathways, reflecting the advantages of multi-level, multi-pathway and multi-targeted treatment of FD.
功能性消化不良（FD）是临床最常见的胃肠疾病，临床症状复杂且迁延不愈。FD的患病率逐年上升，严重影响患者生活质量。FD的主要病因与胃肠动力异常、内脏敏感性增加、幽门螺杆菌（HP）感染、肠道菌群紊乱及心理因素有关。查阅相关文献发现，中医治疗FD的机制主要涉及以下信号通路：5-羟色胺（5-HT）信号通路、腺苷酸活化蛋白激酶（AMPK）信号通路、原癌基因C-kit信号通路、促肾上腺皮质激素释放因子（CRF）信号通路、蛋白激酶R样内质网激酶（PERK）信号通路、核因子κB（NF-κB）信号通路。中医基于整体观念，通过多条信号通路促进胃肠动力、调节内脏敏感性、减轻胃肠炎症，体现了对FD进行多层次、多途径、多靶点治疗的优势。
