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奥扎莫德治疗溃疡性结肠炎合并多发性硬化症患者:一石二鸟。

Ozanimod Therapy in a Patient With Ulcerative Colitis and Multiple Sclerosis: Hitting 2 Birds With 1 Stone.

作者信息

Vuyyuru Sudheer K, Morrow Sarah A, Jairath Vipul

机构信息

Department of Medicine, Division of Gastroenterology, Schulich School of Medicine, Western University, London, Ontario, Canada.

Department of Clinical Neurological Sciences, Schulich School of Medicine, Western University, London, Ontario, Canada.

出版信息

ACG Case Rep J. 2023 Jan 20;10(1):e00955. doi: 10.14309/crj.0000000000000955. eCollection 2023 Jan.

DOI:10.14309/crj.0000000000000955
PMID:36699181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9857283/
Abstract

Simultaneous occurrence of multiple sclerosis (MS) and ulcerative colitis (UC) is seldom encountered by clinicians and poses unique challenges. The sphingosine-1-phosphate receptor modulator ozanimod has been recently approved for UC. Ozanimod can be used in such scenarios where it can treat both conditions, reducing the need for multiple targeted therapies. We report the first case of successfully treated multiple sclerosis and UC with ozanimod.

摘要

临床医生很少遇到多发性硬化症(MS)和溃疡性结肠炎(UC)同时发生的情况,这带来了独特的挑战。鞘氨醇-1-磷酸受体调节剂奥扎莫德最近已被批准用于治疗UC。奥扎莫德可用于能同时治疗这两种病症的情况,减少了对多种靶向治疗的需求。我们报告了首例使用奥扎莫德成功治疗多发性硬化症和UC的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ed0/9857283/aacc4a60d64a/ac9-10-e00955-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ed0/9857283/2923b3fe3d23/ac9-10-e00955-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ed0/9857283/14c4534bc455/ac9-10-e00955-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ed0/9857283/aacc4a60d64a/ac9-10-e00955-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ed0/9857283/2923b3fe3d23/ac9-10-e00955-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ed0/9857283/14c4534bc455/ac9-10-e00955-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ed0/9857283/aacc4a60d64a/ac9-10-e00955-g003.jpg

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1
Ozanimod Therapy in a Patient With Ulcerative Colitis and Multiple Sclerosis: Hitting 2 Birds With 1 Stone.奥扎莫德治疗溃疡性结肠炎合并多发性硬化症患者:一石二鸟。
ACG Case Rep J. 2023 Jan 20;10(1):e00955. doi: 10.14309/crj.0000000000000955. eCollection 2023 Jan.
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An overview of ozanimod as a therapeutic option for adults with moderate-to-severe active ulcerative colitis.奥扎莫德作为一种治疗成人中重度活动性溃疡性结肠炎的治疗选择的概述。
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A critical review of ozanimod for the treatment of adults with moderately to severely active ulcerative colitis.对奥扎莫德治疗中度至重度活动性溃疡性结肠炎成人患者的批判性综述。
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In vitro assessment of the binding and functional responses of ozanimod and its plasma metabolites across human sphingosine 1-phosphate receptors.奥扎莫德及其血浆代谢物与人1-磷酸鞘氨醇受体结合和功能反应的体外评估。
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Ozanimod-exposed Patients with Ulcerative Colitis Undergoing Total Colectomy Exhibit Unique Lymph Node Histological Changes.接受奥扎莫德治疗的溃疡性结肠炎患者行全结肠切除术时表现出独特的淋巴结组织学改变。
J Crohns Colitis. 2024 Apr 23;18(4):638-641. doi: 10.1093/ecco-jcc/jjad174.

本文引用的文献

1
Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel disease.鞘氨醇 1-磷酸调节与炎症性肠病中的免疫细胞迁移。
Nat Rev Gastroenterol Hepatol. 2022 Jun;19(6):351-366. doi: 10.1038/s41575-021-00574-7. Epub 2022 Feb 14.
2
Multiple sclerosis and inflammatory bowel disease: A systematic review and meta-analysis.多发性硬化症与炎症性肠病:系统回顾与荟萃分析。
Ann Clin Transl Neurol. 2022 Feb;9(2):132-140. doi: 10.1002/acn3.51495. Epub 2022 Jan 29.
3
Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis.
奥扎莫德用于溃疡性结肠炎的诱导缓解和维持治疗。
N Engl J Med. 2021 Sep 30;385(14):1280-1291. doi: 10.1056/NEJMoa2033617.
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Reframing Immune-Mediated Inflammatory Diseases through Signature Cytokine Hubs.通过标志性细胞因子中心重塑免疫介导的炎症性疾病
N Engl J Med. 2021 Aug 12;385(7):628-639. doi: 10.1056/NEJMra1909094.
5
Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions.鞘氨醇-1-磷酸受体调节剂在多发性硬化症及其他病症中的应用
Lancet. 2021 Sep 25;398(10306):1184-1194. doi: 10.1016/S0140-6736(21)00244-0. Epub 2021 Jun 24.
6
Fingolimod-induced remission in a patient with ulcerative colitis and multiple sclerosis.芬戈莫德诱导溃疡性结肠炎合并多发性硬化症患者病情缓解。
Gastroenterol Hepatol. 2021 Feb;44(2):156-157. doi: 10.1016/j.gastrohep.2020.07.020. Epub 2020 Nov 14.
7
Impact of immune-mediated diseases in inflammatory bowel disease and implications in therapeutic approach.免疫介导性疾病对炎症性肠病的影响及其在治疗方法中的意义。
Sci Rep. 2020 Jul 1;10(1):10731. doi: 10.1038/s41598-020-67710-2.
8
Ozanimod induction therapy for patients with moderate to severe Crohn's disease: a single-arm, phase 2, prospective observer-blinded endpoint study.奥扎莫德诱导疗法治疗中重度克罗恩病患者:单臂、2 期、前瞻性观察者设盲终点研究。
Lancet Gastroenterol Hepatol. 2020 Sep;5(9):819-828. doi: 10.1016/S2468-1253(20)30188-6. Epub 2020 Jun 15.
9
Clinical Features and Genetic Risk of Demyelination Following Anti-TNF Treatment.抗 TNF 治疗后脱髓鞘的临床特征和遗传风险。
J Crohns Colitis. 2020 Dec 2;14(12):1653-1661. doi: 10.1093/ecco-jcc/jjaa104.
10
Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (RADIANCE): a multicentre, randomised, 24-month, phase 3 trial.奥扎莫德与干扰素β-1a 在复发型多发性硬化症(RADIANCE)中的安全性和疗效:一项多中心、随机、24 个月、3 期临床试验。
Lancet Neurol. 2019 Nov;18(11):1021-1033. doi: 10.1016/S1474-4422(19)30238-8. Epub 2019 Sep 3.