Gastroenterology Department, Marques de Valdecilla University Hospital - IDIVAL, Santander, Cantabria, Spain.
Sci Rep. 2020 Jul 1;10(1):10731. doi: 10.1038/s41598-020-67710-2.
Inflammatory bowel diseases (IBD) belong to the group of immune-mediated diseases (IMIDs). The effect of associated IMIDs in the prognosis in IBD is nowadays unknown. To describe IMIDs associated to IBD patients and evaluate differences linked to the presence or absence of IMIDs. A unicentric retrospective descriptive study was designed. A cohort of 1,448 patients were categorized according to the presence of IMIDs. Clinical characteristics were obtained from IBD database. Univariate and multivariate analysis were performed. 385 patients were diagnosed with associated IMIDs while 1,063 had no associated IMIDs. A prevalence of 26.6% IMIDs associated to IBD was observed. Asthma, skin psoriasis and rheumatoid diseases were most commonly found. Factors associated to the presence of IMIDs were women (OR 1.48; 95 CI 1.17-1.87) and Crohn's disease (OR 1.35; 95 CI 1.07-1.70). Patients with associated IMIDs required more immunomodulator (OR 1.61; 95 CI 1.27-2.43) and biological treatment (OR 1.81; 95 CI 1.47-2.43). More surgical risk was observed in multivariate analysis in those patients diagnosed with IMIDs prior to the onset of IBD (OR 3.71; 95% CI 2.1-6.56). We considered the presence of IMIDs a poor prognostic factor and suggest a closer monitoring of these patients.
炎症性肠病（IBD）属于免疫介导性疾病（IMIDs）。目前尚不清楚相关 IMIDs 对 IBD 预后的影响。本研究旨在描述与 IBD 相关的 IMIDs，并评估与有无 IMIDs 相关的差异。这是一项单中心回顾性描述性研究。我们根据是否存在 IMIDs 将 1448 例患者分为两组。从 IBD 数据库中获取临床特征。进行单因素和多因素分析。385 例患者被诊断为合并 IMIDs，1063 例患者无合并 IMIDs。观察到 IBD 合并 IMIDs 的患病率为 26.6%。最常见的是哮喘、皮肤银屑病和类风湿性疾病。与存在 IMIDs 相关的因素包括女性（OR 1.48；95%CI 1.17-1.87）和克罗恩病（OR 1.35；95%CI 1.07-1.70）。合并 IMIDs 的患者需要更多的免疫调节剂（OR 1.61；95%CI 1.27-2.43）和生物治疗（OR 1.81；95%CI 1.47-2.43）。多因素分析显示，在 IBD 发病前诊断出 IMIDs 的患者手术风险更高（OR 3.71；95%CI 2.1-6.56）。我们认为存在 IMIDs 是一个不良预后因素，并建议对这些患者进行更密切的监测。
