氨甲环酸成功治疗患有小肠静脉畸形导致反复明显胃肠道出血的特纳综合征。
Tranexamic Acid as a Successful Therapy in Turner Syndrome With Recurrent Overt Gastrointestinal Bleeding due to Small Intestinal Venous Anomalies.
作者信息
Lertwilaiwittaya Pongtawat, Weber Frederick H
机构信息
Tinsley Harrison Internal Medicine Residency Program, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Department of Genetics, University of Alabama at Birmingham, Birmingham, AL.
出版信息
ACG Case Rep J. 2023 Jan 20;10(1):e00961. doi: 10.14309/crj.0000000000000961. eCollection 2023 Jan.
Small intestinal venous abnormalities are an underrecognized condition as an etiology of overt gastrointestinal (GI) bleeding in patients with Turner syndrome. Evidence-based therapeutic options for these lesions are lacking in the published literature. A 47-year-old woman with Turner syndrome with a 30-year course of recurrent GI bleeding was found to harbor diffuse small intestinal venous ectasias through endoscopic imaging. Achievement of a 21-month clinical remission (elimination of hospitalizations for overt GI bleeding and normalization of hemoglobin concentration) was reached after initiation of tranexamic acid titrated to 2,600 mg daily.
小肠静脉异常作为特纳综合征患者显性胃肠道（GI）出血的病因，是一种未得到充分认识的病症。已发表的文献中缺乏针对这些病变的循证治疗方案。一名患有特纳综合征且有30年复发性GI出血病史的47岁女性，通过内镜成像发现患有弥漫性小肠静脉扩张。在开始使用氨甲环酸并滴定至每日2600毫克后，实现了21个月的临床缓解（消除显性GI出血导致的住院情况，血红蛋白浓度恢复正常）。
Zotero 插件