Swiergiel A H, Peters G
Institut de Pharmacologie de l'Université de Lausanne, Switzerland.
Life Sci. 1987 Nov 9;41(19):2251-4. doi: 10.1016/0024-3205(87)90523-6.
Single injections of noradrenaline (NA) into the hypothalamic paraventricular nucleus (PVN) initiate short bouts of eating in the rat. The effect of the injections of NA (40 nM) into the PVN on gnawing was studied in satiated male rats that had displayed a reliable eating response to NA. The NA injections produced numerous bouts of prolonged and vigorous gnawing of wood pieces shaped like food pellets. The gnawing response started 0.5-2 min after the injection of NA and lasted for 20-25 min. The results suggest that the increase in gnawing and eating evoked by NA might be related to facilitation of the oral responses, and a changed sensitivity to the food related stimuli, in addition to an intrinsic increase in appetite.
向下丘脑室旁核（PVN）单次注射去甲肾上腺素（NA）可引发大鼠短时间的进食行为。本研究在已对NA表现出可靠进食反应的饱腹雄性大鼠中，探究了向PVN注射NA（40 nM）对啃咬行为的影响。注射NA后，大鼠出现多次长时间且剧烈地啃咬形似食物颗粒的木块的行为。啃咬反应在注射NA后0.5 - 2分钟开始，持续20 - 25分钟。结果表明，NA引起的啃咬和进食增加可能与口腔反应的促进、对食物相关刺激的敏感性变化有关，此外还与食欲的内在增加有关。
