Zhang Xiaoyan, Li Cong, Chen Wenjuan, Wang Guanhua, Zou Huiru, Liu Hao
Central Laboratory, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.
Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China.
Front Chem. 2023 Jan 9;10:1106791. doi: 10.3389/fchem.2022.1106791. eCollection 2022.
Chemiluminescence (CL), a distinct luminescent process by taking advantage of chemical reactions rather than external light source, has recently attracted considerable research interests due to its high sensitivity and low background signal. The sensitivity and specificity of chemiluminescent signals in complex tumor microenvironment provide a sound basis for accurate detection of tumors. Various chemiluminescent nanoprobes with superior performance have been obtained by structural modification of chemiluminescent units or introduction of fluorescent dyes. In this review, we focused on the recent progress of chemiluminescent polymeric systems based on various chromophore substrates, including luminol, peroxyoxalates, 1, 2-dioxetanes and their derivatives for tumor detecting. And we also emphasized the design strategies, mechanisms and diagnostic applications of representative chemiluminescent polymeric nanoprobes. Finally, the critical challenges and perspectives of chemiluminescent systems usage in tumor diagnosis were also discussed.
化学发光（CL）是一种独特的发光过程，它利用化学反应而非外部光源，由于其高灵敏度和低背景信号，近年来引起了相当大的研究兴趣。复杂肿瘤微环境中化学发光信号的灵敏度和特异性为肿瘤的准确检测提供了坚实的基础。通过对化学发光单元进行结构修饰或引入荧光染料，已经获得了各种性能优异的化学发光纳米探针。在这篇综述中，我们重点关注了基于各种发色团底物（包括鲁米诺、过氧草酸酯、1,2-二氧杂环丁烷及其衍生物）的化学发光聚合物体系在肿瘤检测方面的最新进展。我们还强调了代表性化学发光聚合物纳米探针的设计策略、作用机制和诊断应用。最后，还讨论了化学发光体系在肿瘤诊断应用中的关键挑战和前景。
