Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, 510220 Guangzhou, China.
Jt Dis Relat Surg. 2023;34(1):42-49. doi: 10.52312/jdrs.2023.842. Epub 2023 Jan 14.
In this meta-analysis, we aimed to compare the differences in surgical site infection (SSI) between triclosan-coated and uncoated sutures after hip and knee arthroplasty.
We searched PubMed, Embase, and Cochrane databases for randomized-controlled studies (RCTs) comparing triclosan-coated sutures with uncoated sutures for the prevention of SSIs after hip and knee arthroplasty. Literature screening and data curation were performed according to inclusion and exclusion criteria and the risk of bias was assessed for included research using Cochrane Handbook criteria.
Three RCTs with a total of 2,689 cases were finally included, including 1,296 cases in the triclosan-coated suture group and 1,393 cases in the control group. The overall incidence of SSI was lower in the group with triclosan antimicrobial sutures (1.9%) than in the uncoated suture group (2.5%), but the difference was statistically significant (odds ratio=0.76, 95% confidence interval: [0.45-1.27], p=0.30). The differences in the results of the incidence of superficial SSI and deep SSI were not statistically significant (p>0.05).
The application of triclosan antimicrobial sutures did not reduce the incidence of SSI after hip and knee arthroplasty compared to the controls, and it needs further high-quality RCT studies to be improved.
在这项荟萃分析中，我们旨在比较髋关节和膝关节置换术后使用三氯生涂层缝线和未涂层缝线在手术部位感染（SSI）方面的差异。
我们检索了 PubMed、Embase 和 Cochrane 数据库，以寻找比较髋关节和膝关节置换术后使用三氯生涂层缝线和未涂层缝线预防 SSI 的随机对照研究（RCT）。根据纳入和排除标准进行文献筛选和数据整理，并使用 Cochrane 手册标准评估纳入研究的偏倚风险。
最终纳入了 3 项 RCT，共 2689 例患者，其中三氯生涂层缝线组 1296 例，对照组 1393 例。三氯生抗菌缝线组 SSI 的总发生率（1.9%）低于未涂层缝线组（2.5%），但差异无统计学意义（比值比=0.76，95%置信区间：[0.45-1.27]，p=0.30）。浅部 SSI 和深部 SSI 的发生率结果差异无统计学意义（p>0.05）。
与对照组相比，应用三氯生抗菌缝线并未降低髋关节和膝关节置换术后 SSI 的发生率，需要进一步开展高质量的 RCT 研究来加以改进。
