Sinicropi Maria Stefania, Iacopetta Domenico, Ceramella Jessica, Catalano Alessia, Mariconda Annaluisa, Pellegrino Michele, Saturnino Carmela, Longo Pasquale, Aquaro Stefano
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.
Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, 70126 Bari, Italy.
Antibiotics (Basel). 2022 May 30;11(6):735. doi: 10.3390/antibiotics11060735.
Triclosan (TCS), a broad-spectrum antimicrobial agent, has been widely used in personal care products, medical products, plastic cutting boards, and food storage containers. Colgate Total toothpaste, containing 10 mM TCS, is effective in controlling biofilm formation and maintaining gingival health. Given its broad usage, TCS is present ubiquitously in the environment. Given its strong lipophilicity and accumulation ability in organisms, it is potentially harmful to biohealth. Several reports suggest the toxicity of this compound, which is inserted in the class of endocrine disrupting chemicals (EDCs). In September 2016, TCS was banned by the U.S. Food and Drug Administration (FDA) and the European Union in soap products. Despite these problems, its application in personal care products within certain limits is still allowed. Today, it is still unclear whether TCS is truly toxic to mammals and the adverse effects of continuous, long-term, and low concentration exposure remain unknown. Indeed, some recent reports suggest the use of TCS as a repositioned drug for cancer treatment and cutaneous leishmaniasis. In this scenario it is necessary to investigate the advantages and disadvantages of TCS, to understand whether its use is advisable or not. This review intends to highlight the pros and cons that are associated with the use of TCS in humans.
三氯生（TCS）是一种广谱抗菌剂，已广泛应用于个人护理产品、医疗产品、塑料砧板和食品储存容器中。含10 mM三氯生的高露洁全效牙膏在控制生物膜形成和维持牙龈健康方面有效。鉴于其广泛使用，三氯生在环境中普遍存在。鉴于其较强的亲脂性和在生物体中的蓄积能力，它可能对生物健康有害。一些报告表明该化合物具有毒性，它被归类为内分泌干扰化学物质（EDCs）。2016年9月，美国食品药品监督管理局（FDA）和欧盟禁止在肥皂产品中使用三氯生。尽管存在这些问题，但在一定限度内它仍被允许用于个人护理产品。如今，三氯生是否真的对哺乳动物有毒以及持续、长期、低浓度接触的不良影响仍不明确。事实上，最近一些报告表明可将三氯生重新定位用于癌症治疗和皮肤利什曼病。在这种情况下，有必要研究三氯生的优缺点，以了解其使用是否明智。本综述旨在强调在人类中使用三氯生的利弊。
