注意缺陷多动障碍成年患者的回避伤害与奖赏系统相关：一项功能磁共振成像研究
Harm Avoidance is Correlated with the Reward System in Adult Patients with Attention Deficit Hyperactivity Disorder: A Functional Magnetic Resonance Imaging Study.
作者信息
Lu Tsung-Hua, Lin Shih-Hsien, Chi Mei Hung, Chu Ching-Lin, Yang Dong-Yu, Chang Wei Hung, Chen Po See, Yang Yen Kuang
机构信息
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
出版信息
Clin Psychopharmacol Neurosci. 2023 Feb 28;21(1):99-107. doi: 10.9758/cpn.2023.21.1.99.
OBJECTIVE
Hypoactivity in the reward system among patients with attention deficit hyperactivity disorder (ADHD) is a well-known phenomenon. Whether the activity in the reward pathway is related to harm avoidance, such as in sensitivity to punishment, is unclear. Evidence regarding the potential difference between ADHD patients and controls in terms of this association is scarce.
METHODS
Event-related functional magnetic resonance imaging was conducted on subjects performing the Iowa gambling test. Fourteen adults with ADHD and 14 controls were enrolled in the study.
RESULTS
Harm avoidance was found to be positively correlated with the activities of the bilateral orbitofrontal cortex and right insula in individuals with ADHD. A group difference was also confirmed.
CONCLUSION
Understanding the roles of harm avoidance and brain activation during risk tasks is important.
目的
注意缺陷多动障碍（ADHD）患者奖赏系统活动减退是一个众所周知的现象。奖赏通路的活动是否与避免伤害有关，如对惩罚的敏感性，尚不清楚。关于ADHD患者与对照组在这种关联方面的潜在差异的证据很少。
方法
对进行爱荷华赌博测试的受试者进行事件相关功能磁共振成像。该研究纳入了14名患有ADHD的成年人和14名对照组。
结果
发现ADHD患者中避免伤害与双侧眶额叶皮质和右侧脑岛的活动呈正相关。还证实了组间差异。
结论
了解在风险任务中避免伤害和大脑激活的作用很重要。
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