Viitaja Tuomo, Raitanen Jan-Erik, Moilanen Jukka, Paananen Riku O, Ekholm Filip S
Department of Chemistry, University of Helsinki, P.O. Box 55, FI-00014 Helsinki, Finland; Ophthalmology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 8, FI-00290 Helsinki, Finland.
Department of Chemistry, University of Helsinki, P.O. Box 55, FI-00014 Helsinki, Finland.
Colloids Surf B Biointerfaces. 2023 Mar;223:113145. doi: 10.1016/j.colsurfb.2023.113145. Epub 2023 Jan 14.
The tear film lipid layer (TFLL) is a unique biological membrane of importance to the maintenance of ocular surface health. The underlying factors at play, e.g. the ability to retard evaporation and offer protection from the environment, are all closely connected to the properties of individual lipid components and their interplay. The TFLL contains unique ultra-long polar lipid species such as O-acyl-ω-hydroxy fatty acids, type I-St diesters and type II diesters, which are considered important for its proper function. Herein, we have synthesized model compounds from these categories and studied their biophysical and surface rheological properties at the aqueous interface. Altogether, we provide insights on the distinct biophysical profiles of these lipid classes and discuss how their interplay may affect the structure and function of the TFLL.
泪膜脂质层（TFLL）是一种对维持眼表健康至关重要的独特生物膜。其发挥作用的潜在因素，例如延缓蒸发的能力以及提供对环境的保护，都与单个脂质成分的特性及其相互作用密切相关。TFLL包含独特的超长极性脂质种类，如O-酰基-ω-羟基脂肪酸、I型-甾醇二酯和II型二酯，它们被认为对其正常功能很重要。在此，我们从这些类别中合成了模型化合物，并研究了它们在水界面的生物物理和表面流变学性质。总之，我们提供了关于这些脂质类别的独特生物物理概况的见解，并讨论了它们的相互作用如何可能影响TFLL的结构和功能。
