Global change is shaping social-ecological systems, threatening both natural and socio-economic ecosystems as a whole. Landscapes with combined nature-human interactions are particularly vulnerable to changing climatic conditions. Therefore, there is a need to find viable and practical solutions for the preservation and recovery of the affected systems. A relevant way to cope with disturbances is to promote social-ecological resilience through the use of strategies targeting the social-ecological system as a whole, in order to ensure an efficient self-reorganization of a landscape. This study presents a research innovation by clarifying the concept of social-ecological resilience while being focused on providing a useful tool for landscape managers. For doing so, the research first defines social-ecological resilience and aims to give a clear idea of its characteristics and application features. Second, it explains the importance of social-ecological resilience for landscapes, focusing on the relationship of humans with nature and traditional ecological knowledge (TEK) for biodiversity conservation. Third, it proposes guidelines and measures for the promotion and enhancement of social-ecological resilience. The outcomes of the study show a broad perspective on the concept of social-ecological resilience to understand the necessary adaptation to global change. As findings, this research highlights the significance of nature-human interactions for agroforestry systems, citing also the potential contribution that digital innovation can play for the conservation of those interactions in a sustainable way. Moreover, it uncovers the key role of local communities in building social-ecological resilience through the application of a variety of described strategies that can have a relevant impact and be useful for landscape management practices to face upcoming challenges linked to climate change.