Ashland LLC, USA.
Saba University School of Medicine, the Netherlands.
Food Chem Toxicol. 2023 Apr;174:113628. doi: 10.1016/j.fct.2023.113628. Epub 2023 Jan 24.
Aloe has a long history of topical and systemic use with testimonials of countless health benefits and is one of the most popular botanical medicines in the world for the management of a wide variety both of benign and serious ailments including irritable bowel syndromes, osteoarthritis, Type II diabetes mellitus, and viral respiratory illness. The human consumption of Aloe vera extract in beverage form has substantially grown over the last several decades, in no small part, due to the increased consumer interest in alternative approaches to health benefits. The principal aim of the present paper is to characterize the research to date that has explored the genotoxic potential of Aloe vera inner leaf gel extract and decolorized whole leaf extract used in commercially available food-grade drinkable products which contain no more than 10 ppm aloin. Despite prevailing public health opinion, especially in Europe, the consensus of the reviewed studies retrieved from the peer-reviewed literature together with a mutagenic evaluation of an Aloe vera whole leaf decolorized spray-dried powder is that these products are not genotoxic.
芦荟具有悠久的局部和全身应用历史，有无数的健康益处的证明，并且是世界上最受欢迎的植物药之一，可用于治疗各种良性和严重疾病，包括肠易激综合征、骨关节炎、II 型糖尿病和病毒性呼吸道疾病。在过去几十年中，以饮料形式消费的库拉索芦荟提取物大幅增加，这在很大程度上是由于消费者对替代健康益处方法的兴趣增加。本文的主要目的是描述迄今为止探索库拉索芦荟内层凝胶提取物和经脱色的全叶提取物的遗传毒性潜力的研究，这些提取物用于商业上可获得的食品级可饮用产品中，其含量不超过 10 ppm 芦荟素。尽管存在普遍的公众健康观点，尤其是在欧洲，但从同行评议文献中检索到的综述研究的共识以及对芦荟全叶脱色喷雾干燥粉末的致突变评估表明，这些产品没有遗传毒性。
