Chelu Mariana, Musuc Adina Magdalena, Popa Monica, Calderon Moreno Jose
"Ilie Murgulescu" Institute of Physical Chemistry, 202 Splaiul Independentei, 060021 Bucharest, Romania.
Gels. 2023 Jul 3;9(7):539. doi: 10.3390/gels9070539.
-based hydrogels have emerged as promising platforms for the delivery of therapeutic agents in wound dressings due to their biocompatibility and unique wound-healing properties. The present study provides a comprehensive overview of recent advances in the application of -based hydrogels for wound healing. The synthesis methods, structural characteristics, and properties of -based hydrogels are discussed. Mechanisms of therapeutic agents released from -based hydrogels, including diffusion, swelling, and degradation, are also analyzed. In addition, the therapeutic effects of -based hydrogels on wound healing, as well as the reduction of inflammation, antimicrobial activity, and tissue regeneration, are highlighted. The incorporation of various therapeutic agents, such as antimicrobial and anti-inflammatory ones, into -based hydrogels is reviewed in detail. Furthermore, challenges and future prospects of -based hydrogels for wound dressing applications are considered. This review provides valuable information on the current status of -based hydrogels for the delivery of therapeutic agents in wound dressings and highlights their potential to improve wound healing outcomes.
基于[具体物质]的水凝胶因其生物相容性和独特的伤口愈合特性,已成为伤口敷料中递送治疗剂的有前景的平台。本研究全面概述了基于[具体物质]的水凝胶在伤口愈合应用中的最新进展。讨论了基于[具体物质]的水凝胶的合成方法、结构特征和性质。还分析了基于[具体物质]的水凝胶释放治疗剂的机制,包括扩散、溶胀和降解。此外,强调了基于[具体物质]的水凝胶对伤口愈合的治疗效果,以及炎症减轻、抗菌活性和组织再生。详细综述了将各种治疗剂,如抗菌和抗炎剂,掺入基于[具体物质]的水凝胶中的情况。此外,还考虑了基于[具体物质]的水凝胶在伤口敷料应用中的挑战和未来前景。本综述提供了关于基于[具体物质]的水凝胶在伤口敷料中递送治疗剂的当前状态的有价值信息,并突出了它们改善伤口愈合结果的潜力。