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用于伤口愈合的水凝胶:特性与治疗效果

-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects.

作者信息

Chelu Mariana, Musuc Adina Magdalena, Popa Monica, Calderon Moreno Jose

机构信息

"Ilie Murgulescu" Institute of Physical Chemistry, 202 Splaiul Independentei, 060021 Bucharest, Romania.

出版信息

Gels. 2023 Jul 3;9(7):539. doi: 10.3390/gels9070539.

Abstract

-based hydrogels have emerged as promising platforms for the delivery of therapeutic agents in wound dressings due to their biocompatibility and unique wound-healing properties. The present study provides a comprehensive overview of recent advances in the application of -based hydrogels for wound healing. The synthesis methods, structural characteristics, and properties of -based hydrogels are discussed. Mechanisms of therapeutic agents released from -based hydrogels, including diffusion, swelling, and degradation, are also analyzed. In addition, the therapeutic effects of -based hydrogels on wound healing, as well as the reduction of inflammation, antimicrobial activity, and tissue regeneration, are highlighted. The incorporation of various therapeutic agents, such as antimicrobial and anti-inflammatory ones, into -based hydrogels is reviewed in detail. Furthermore, challenges and future prospects of -based hydrogels for wound dressing applications are considered. This review provides valuable information on the current status of -based hydrogels for the delivery of therapeutic agents in wound dressings and highlights their potential to improve wound healing outcomes.

摘要

基于[具体物质]的水凝胶因其生物相容性和独特的伤口愈合特性,已成为伤口敷料中递送治疗剂的有前景的平台。本研究全面概述了基于[具体物质]的水凝胶在伤口愈合应用中的最新进展。讨论了基于[具体物质]的水凝胶的合成方法、结构特征和性质。还分析了基于[具体物质]的水凝胶释放治疗剂的机制,包括扩散、溶胀和降解。此外,强调了基于[具体物质]的水凝胶对伤口愈合的治疗效果,以及炎症减轻、抗菌活性和组织再生。详细综述了将各种治疗剂,如抗菌和抗炎剂,掺入基于[具体物质]的水凝胶中的情况。此外,还考虑了基于[具体物质]的水凝胶在伤口敷料应用中的挑战和未来前景。本综述提供了关于基于[具体物质]的水凝胶在伤口敷料中递送治疗剂的当前状态的有价值信息,并突出了它们改善伤口愈合结果的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d5/10379830/b1586976d569/gels-09-00539-g001.jpg

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