Langabeer Stephen E
Cancer Molecular Diagnostics, St James's Hospital, Dublin, Ireland.
Clin Exp Dermatol. 2023 Apr 27;48(5):555-556. doi: 10.1093/ced/llad037.
Pyoderma gangrenosum can be associated with haematological malignancies but rarely a myeloproliferative neoplasm. A review of requests for molecular detection of myeloproliferative neoplasm driver mutations in patients with pyoderma gangrenosum was performed and revealed that testing for these mutations is unwarranted in cases where there are no clinical, haematological or morphological features of a myeloproliferative neoplasm present.
坏疽性脓皮病可与血液系统恶性肿瘤相关，但很少与骨髓增殖性肿瘤相关。我们对坏疽性脓皮病患者进行骨髓增殖性肿瘤驱动基因突变分子检测的申请进行了回顾，结果显示，在没有骨髓增殖性肿瘤的临床、血液学或形态学特征的情况下，对这些突变进行检测是没有必要的。
