前列腺癌调强放疗（IMRT）和容积旋转调强放疗（VMAT）的分析剂量学研究。
Analytical dosimetric study of intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) for prostate cancer.
机构信息
Alexandria Clinical Oncology Department, Alexandria University, Alexandria, Egypt.
Physics Department Faculty of Science, Tanta University, Tanta, Egypt.
出版信息
J Cancer Res Clin Oncol. 2023 Aug;149(9):6239-6246. doi: 10.1007/s00432-023-04586-5. Epub 2023 Jan 27.
PURPOSE
The study aimed to compare the dosimetric results and treatment delivery efficiency among four techniques to explore the preferred technique in prostate treatment.
MATERIALS AND METHODS
7 IMRT, 9 IMRT, 1 ARC, and 2 ARC plans were created for 30 prostate cancer patients using the Eclipse™ treatment planning system (Varian Medical Systems). All the plans were designed to deliver 80.0 Gy in 40 fractions to the prostate planning target volume (PTV). Target coverage, organs at risk (OARs), number of monitor units, homogeneity, and conformity were compared across the four techniques to assess the quality of the plans.
RESULTS
The study revealed better Planning Target Volume (PTV) dose coverage in the VMAT-2A than in the other plans. At the same time, VMAT-2A plans were found to be significantly lower in terms of Bladder and rectum doses than other techniques. In addition, VMAT has the advantage of considerably reducing the number of monitor units and treatment time.
CONCLUSION
For prostate cancer, VMAT may offer a favorable dose gradient profile, conformity, and MU and treatment time compared to IMRT.
目的
本研究旨在比较四种技术的剂量学结果和治疗效率，以探索前列腺治疗中首选的技术。
材料与方法
使用 Eclipse™ 治疗计划系统（Varian Medical Systems）为 30 名前列腺癌患者创建了 7 个 IMRT、9 个 IMRT、1 个 ARC 和 2 个 ARC 计划。所有计划均旨在将 80.0 Gy 分 40 次递送至前列腺计划靶区（PTV）。比较了四种技术的靶区覆盖、危及器官（OARs）、监测器单位数、均匀性和适形性，以评估计划的质量。
结果
研究表明，VMAT-2A 比其他计划更好地覆盖了计划靶区（PTV）的剂量。同时，VMAT-2A 计划在膀胱和直肠剂量方面明显低于其他技术。此外，VMAT 在显著减少监测器单位数和治疗时间方面具有优势。
结论
对于前列腺癌，与 IMRT 相比，VMAT 可能在剂量梯度分布、适形性、MU 和治疗时间方面具有优势。
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