Farrahi Vahid, Rostami Mehrdad, Nauha Laura, Korpisaari Maija, Niemelä Maisa, Jämsä Timo, Korpelainen Raija, Oussalah Mourad
Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
Center of Machine Vision and Signal Analysis, Faculty of Information Technology, University of Oulu, Oulu, Finland.
Scand J Med Sci Sports. 2023 Jun;33(6):907-920. doi: 10.1111/sms.14323. Epub 2023 Feb 8.
This study aimed to examine the associations of sedentary time, and substituting sedentary time with physical activity and sleep, with cardiometabolic health markers while accounting for a full 24 h of movement and non-movement behaviors, cardiorespiratory fitness (CRF), and other potential confounders. The participants were 4585 members of the Northern Finland Birth Cohort 1966, who wore a hip-worn accelerometer at the age of 46 years for 14 consecutive days. Time spent in sedentary behaviors, light-intensity physical activity (LPA), and moderate-to-vigorous-intensity physical activity (MVPA) were determined from the accelerometer and combined with self-reported sleep duration to obtain the 24-h time use. CRF was estimated from the peak heart rate in a submaximal step test. An isotemporal substitution paradigm was used to examine how sedentary time and substituting sedentary time with an equal amount of LPA, MVPA, or sleep were associated with adiposity markers, blood lipid levels, and fasting glucose and insulin. Sedentary time was independently and adversely associated with the markers of cardiometabolic health, even after adjustment for CRF, but not in partition models including LPA, MVPA, sleep, and CRF. Substituting 60, 45, 30, and 15 min/day of sedentary time with LPA or MVPA was associated with 0.2%-13.7% favorable differences in the cardiometabolic health markers after accounting for LPA, MVPA, sleep, CRF, and other confounders. After adjustment for movement and non-movement behaviors within the 24-h cycle, reallocating additional time to both LPA and MVPA was beneficially associated with markers of cardiometabolic health in middle-aged adults regardless of their CRF level.
本研究旨在探讨久坐时间，以及用身体活动和睡眠替代久坐时间，与心血管代谢健康指标之间的关联，同时考虑到24小时的活动和非活动行为、心肺适能（CRF）以及其他潜在混杂因素。参与者为1966年芬兰北部出生队列的4585名成员，他们在46岁时连续14天佩戴髋部加速计。通过加速计确定久坐行为、轻度身体活动（LPA）和中度至剧烈身体活动（MVPA）所花费的时间，并结合自我报告的睡眠时间以获得24小时的时间使用情况。通过次极量台阶试验中的心率峰值来估计CRF。采用等时替代范式来研究久坐时间以及用等量的LPA、MVPA或睡眠替代久坐时间如何与肥胖指标、血脂水平以及空腹血糖和胰岛素相关联。即使在对CRF进行调整之后，久坐时间仍与心血管代谢健康指标独立且呈负相关，但在包括LPA、MVPA、睡眠和CRF的分区模型中并非如此。在用LPA或MVPA替代每天60、45、30和15分钟的久坐时间后，在考虑LPA、MVPA、睡眠、CRF和其他混杂因素后，心血管代谢健康指标出现了0.2%-13.7%的有利差异。在对24小时周期内的活动和非活动行为进行调整之后，无论CRF水平如何，将更多时间重新分配给LPA和MVPA均与中年成年人的心血管代谢健康指标呈有益关联。
