Department of Pharmaceutical Sciences Maharshi Dayanand University, Rohtak, Haryana, 124001, India.
Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani, Haryana, 127031, India.
Curr Neuropharmacol. 2023;21(12):2487-2504. doi: 10.2174/1570159X21666230126151208.
Traumatic brain injury (TBI) is a worldwide problem. Almost about sixtynine million people sustain TBI each year all over the world. Repetitive TBI linked with increased risk of neurodegenerative disorder such as Parkinson, Alzheimer, traumatic encephalopathy. TBI is characterized by primary and secondary injury and exerts a severe impact on cognitive, behavioral, psychological and other health problem. There were various proposed mechanism to understand complex pathophysiology of TBI but still there is a need to explore more about TBI pathophysiology. There are drugs present for the treatment of TBI in the market but there is still need of more drugs to develop for better and effective treatment of TBI, because no single drug is available which reduces the further progression of this injury.
The main aim and objective of structuring this manuscript is to design, develop and gather detailed data regarding about the pathophysiology of TBI and role of medicinal plants in its treatment.
This study is a systematic review conducted between January 1995 to June 2021 in which a consultation of scientific articles from indexed periodicals was carried out in Science Direct, United States National Library of Medicine (Pubmed), Google Scholar, Elsvier, Springer and Bentham.
A total of 54 studies were analyzed, on the basis of literature survey in the research area of TBI.
Recent studies have shown the potential of medicinal plants and their chemical constituents against TBI therefore, this review targets the detailed information about the pathophysiology of TBI and role of medicinal plants in its treatment.
创伤性脑损伤（TBI）是一个全球性问题。全世界每年约有 6900 万人遭受 TBI。与神经退行性疾病（如帕金森、阿尔茨海默病、创伤性脑病）风险增加相关的重复性 TBI。TBI 的特征是原发性和继发性损伤，对认知、行为、心理和其他健康问题产生严重影响。已经提出了各种机制来了解 TBI 的复杂病理生理学，但仍需要更多地探索 TBI 的病理生理学。市场上有治疗 TBI 的药物，但仍需要开发更多的药物来更好、更有效地治疗 TBI，因为没有一种单一的药物可以减少这种损伤的进一步进展。
构建本手稿的主要目的和目标是设计、开发和收集有关 TBI 病理生理学和药用植物在其治疗中的作用的详细数据。
这是一项系统评价，于 1995 年 1 月至 2021 年 6 月进行，在 Science Direct、美国国家医学图书馆（Pubmed）、Google Scholar、Elsvier、Springer 和 Bentham 等索引期刊中检索科学文章。
共分析了 54 项研究，这些研究是基于对 TBI 研究领域的文献调查。
最近的研究表明药用植物及其化学成分对 TBI 的潜在作用，因此，本综述的目的是详细介绍 TBI 的病理生理学和药用植物在其治疗中的作用。
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