1550纳米铒玻璃激光与CO2点阵激光治疗白色萎缩纹的自身对照研究
Treatment of striae albae with 1,550 nm Er: Glass vs. CO fractional laser: A self-controlled study.
作者信息
Luo Yanfei, Lin Yan, Wang Meiling, Gao Xiaoyuan, Liu Xiaodong, Liu Huaxu
机构信息
Department of Dermatology, Hainan General Hospital, Haikou, Hainan, China.
Shandong Provincial Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
出版信息
Front Med (Lausanne). 2023 Jan 10;9:1060815. doi: 10.3389/fmed.2022.1060815. eCollection 2022.
OBJECTIVE
The objective of this study was to compare the efficacy and safety of fractional CO laser and 1,550 nm Er: glass laser in the treatment for the patients with striae albae.
METHODS
The female adults with striae albae in the abdomen for at least 12 months were recruited. After informed consent obtained, the patient received three treatments at 2-month intervals. The lesions on the left abdomen were treated with 10,600 nm CO fractional laser and right side treated with 1,550 nm Er: glass fractional laser. The pictures were taken before each visit and 3 months after the final treatment. The criteria for the evaluations using a quartile grading scale were excellent (76-100%), good (51-75%), fair (26-50%), poor (1-25%), and no improvement (0%). The safety and efficacy of the two lasers were independently evaluated using before and after photographs by two dermatologists. In addition, the self-reports to investigate the pain and satisfaction from patients were also recorded.
RESULTS
Totally, 27 cases were recruited, and 25 patients completed the treatments and follow-up. The excellent and good results (improvement of 51-100%) were achieved on the right abdomen in 84% of the patients, while 48% on the left site ( < 0.05). Hyper-pigmentation was seen in 20% of the patients assessed on the left abdomen and only in 8% on the right abdomen. During the treatments, average score of the pain on the right abdomen was 5.41 ± 2.13, which was higher than that on the left (4.19 ± 2.12) ( < 0.001). No permanent hyper-pigmentation was found on the both sides. Considering the whole treatments, the patients favored the modality used on the right side (80 vs. 68%, < 0.05).
CONCLUSION
Compared with CO fractional laser, 1,550 nm Er: glass fractional laser therapy provides the significantly better clinical outcomes and fewer side effects in the treatment of striae albae.
LIMITATIONS
The sample size and follow-up time were limited.
目的
本研究旨在比较剥脱性二氧化碳激光和1550nm铒玻璃激光治疗白色妊娠纹患者的疗效和安全性。
方法
招募腹部有白色妊娠纹至少12个月的成年女性。在获得知情同意后，患者每隔2个月接受3次治疗。左腹部的皮损用10600nm剥脱性二氧化碳激光治疗，右腹部用1550nm铒玻璃剥脱性激光治疗。每次就诊前及最后一次治疗后3个月拍照。使用四分位数分级量表进行评估的标准为：优秀（76-100%）、良好（51-75%）、中等（26-50%）、差（1-25%）和无改善（0%）。两位皮肤科医生通过治疗前后的照片独立评估两种激光的安全性和疗效。此外，还记录了患者关于疼痛和满意度的自我报告。
结果
共招募27例患者，25例患者完成治疗及随访。84%的患者右腹部达到优秀和良好效果（改善51-100%），而左腹部为48%（<0.05）。左腹部评估的患者中有20%出现色素沉着，右腹部仅为8%。治疗期间，右腹部疼痛平均评分为5.41±2.13，高于左腹部（4.19±2.12）（<0.001）。两侧均未发现永久性色素沉着。考虑整个治疗过程，患者更倾向于右侧使用的治疗方式（80%对68%，<0.05）。
结论
与剥脱性二氧化碳激光相比，1550nm铒玻璃剥脱性激光治疗白色妊娠纹的临床效果显著更好，副作用更少。
局限性
样本量和随访时间有限。
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