儿童及青少年甲状腺乳头状癌超声与病理特征比较
Comparison of ultrasonography and pathology features between children and adolescents with papillary thyroid carcinoma.
作者信息
Jie Yue, Ruan Jingliang, Cai Yuechang, Luo Man, Liu Rongbin
机构信息
Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital Sun Yat-Sen University, Guangzhou, China.
出版信息
Heliyon. 2023 Jan 12;9(1):e12828. doi: 10.1016/j.heliyon.2023.e12828. eCollection 2023 Jan.
OBJECTIVE
To compare the ultrasonography and pathology features between children and adolescents with papillary thyroid carcinoma (PTC).
METHODS
A total of 53 patients who were surgically diagnosed with childhood or adolescent PTC between 2017 and 2022 were included in this study. The pre-operative ultrasonography, post-operative histology, and molecular and clinical characteristics were retrospectively analyzed.
RESULTS
No differences were observed in composition, echogenicity, and shape using ultrasonography. Moreover, there was a significantly higher rate of extrathyroidal extension, punctate echogenic foci, and lymph node metastases in children compared to adolescents. The molecular analysis showed that BRAF mutations are the most prevalent abnormality in adolescent PTC (12/20, 60.0%). However, they are less in childhood PTC (7/23, 30.4%). In addition, using next-generation sequencing, three cases with oncogenic fusion (one TRIM33-RET case, one CCDC6-RET case, and one STRN-ALK case) were identified in childhood PTC.
CONCLUSION
The frequency of extrathyroidal extension, punctate echogenic foci, and lymph node metastases were higher in childhood PTC, while BRAF mutations were higher in adolescent PTC.
目的
比较儿童和青少年甲状腺乳头状癌（PTC）的超声检查和病理特征。
方法
本研究纳入了2017年至2022年间经手术确诊为儿童或青少年PTC的53例患者。对术前超声检查、术后组织学以及分子和临床特征进行回顾性分析。
结果
超声检查在成分、回声和形态方面未观察到差异。此外，与青少年相比，儿童甲状腺外侵犯、点状强回声灶和淋巴结转移的发生率显著更高。分子分析表明，BRAF突变是青少年PTC中最常见的异常（12/20，60.0%）。然而，在儿童PTC中较少见（7/23，30.4%）。此外，通过二代测序，在儿童PTC中鉴定出3例致癌融合病例（1例TRIM33-RET病例、1例CCDC6-RET病例和1例STRN-ALK病例）。
结论
儿童PTC中甲状腺外侵犯、点状强回声灶和淋巴结转移的发生率较高，而青少年PTC中BRAF突变率较高。
Zotero 插件