Zec Ivana, Goldštajn Marina Šprem, Kuna Krunoslav, Mikuš Mislav, Stabile Guglielmo, Bianco Bianca, Buzzaccarini Giovanni, Laganà Antonio Simone
Laboratory of Endocrinology, Department of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia.
Department of Obstetrics and Gynaecology, Division of Reproductive Endocrinology and Reproductive Medicine, Zagreb University Hospital Centre, University of Zagreb, School of Medicine, Zagreb, Croatia.
Prz Menopauzalny. 2022 Dec;21(4):276-284. doi: 10.5114/pm.2022.124019. Epub 2022 Dec 30.
Free radicals and oxidant molecules are part of our organism in a stable balance. However, when addressing female infertility, questions about their role in oocyte quality arise. This review outlines the major alterations of redox homeostasis in the follicular fluid through pathophysiological conditions in female reproduction and its potential effect on IVF outcome. A review of the literature was accurately performed. Manuscripts investigating follicular fluid biomarkers, especially related to oxidant molecules, were screened and used in this review. Studies assessing the follicular reactive species were found and screened. Moreover, studies assessing the IVF outcomes related to biomarkers were considered. The results are provided in an analytical pathway. The study of biomarkers confirms the shift to enhanced oxidizing modification of macromolecules and antioxidative consumption in the follicular fluid of women undergoing IVF treatment. A lack of congruency in methods appears to be marked in the design of scientific studies. However, it is not clear whether redox disbalance has a disruptive effect on the oocyte competence or whether it plays a role in the oocyte maturation process. Red-ox balance plays a questionable role in IVF outcomes. Possible further insights may consider the antioxidant role of adjuvants during controlled ovarian stimulation cycles.
自由基和氧化分子是我们机体处于稳定平衡状态时的一部分。然而，在探讨女性不孕症时，它们在卵母细胞质量方面的作用问题随之而来。本综述概述了女性生殖生理病理状况下卵泡液中氧化还原稳态的主要改变及其对体外受精（IVF）结局的潜在影响。对文献进行了准确的检索。筛选并使用了研究卵泡液生物标志物，尤其是与氧化分子相关的生物标志物的手稿。查找并筛选了评估卵泡反应性物质的研究。此外，还考虑了评估与生物标志物相关的IVF结局的研究。结果以分析路径呈现。生物标志物的研究证实，接受IVF治疗的女性卵泡液中大分子的氧化修饰增强和抗氧化消耗增加。科学研究设计中方法缺乏一致性的问题较为明显。然而，尚不清楚氧化还原失衡是否对卵母细胞能力有破坏作用，或者它是否在卵母细胞成熟过程中发挥作用。氧化还原平衡在IVF结局中所起的作用存疑。可能的进一步见解可考虑辅助剂在控制性卵巢刺激周期中的抗氧化作用。
