家用高强度聚焦超声设备在减少皱纹方面的疗效。
Efficacy of a home-used high-intensity focused ultrasound device on wrinkle reduction.
机构信息
Department of Immunology, School of Medicine, Kyungpook National University, Daegu, South Korea.
BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University, Daegu, South Korea.
出版信息
Skin Res Technol. 2023 Jan;29(1):e13266. doi: 10.1111/srt.13266.
BACKGROUND
High-intensity focused ultrasound (HIFU) has been developed for the treatment of skin wrinkles on the face, neck, and body.
OBJECTIVES
This study aimed to evaluate the effects of a home-used HIFU device on wrinkles in mice based on the expression of fibrosis-related genes and proteins.
METHODS
The backs of 20-week-old mice were treated with a home-used HIFU using the following probes: 4 MHz, 1.5 mm focal depth. The treated mice were compared with young mice by histological examination, real-time polymerase chain reaction (PCR), and immunohistochemistry. Histological examination was performed by trichrome staining. Real-time PCR and immunohistochemistry were conducted to determine the expression of collagen types I and III, matrix metalloproteinase (MMP)-1, and tissue inhibitor of metalloproteinase (TIMP)-1.
RESULTS
Dermal thickness was increased after treatment with the home-used HIFU device at 30 and 60 s per day for 1 week or 30 and 60 s per day for 2 weeks on trichrome. Gene and protein expression of collagen types I and III and elastin were increased after treatment with HIFU at all options of 30 and 60 s per day for 1 week or 30 and 60 s per day for 2 weeks. Gene and protein expressions of MMP-1 and TIMP-1 were decreased after treatment with HIFU device at 30 and 60 s per day for 1 week or 30 and 60 s per day for 2 weeks.
CONCLUSION
The home-used HIFU device can be an effective therapeutic modality for skin tightening.
背景
高强度聚焦超声（HIFU）已被开发用于治疗面部、颈部和身体的皮肤皱纹。
目的
本研究旨在通过纤维化相关基因和蛋白的表达，评估家用 HIFU 设备对小鼠皱纹的影响。
方法
20 周龄小鼠背部用 4MHz、1.5mm 焦点深度的家用 HIFU 探头进行处理。通过组织学检查、实时聚合酶链反应（PCR）和免疫组织化学比较处理后的小鼠与年轻小鼠。组织学检查采用三色染色。实时 PCR 和免疫组织化学用于确定 I 型和 III 型胶原、基质金属蛋白酶（MMP）-1 和金属蛋白酶组织抑制剂（TIMP）-1 的表达。
结果
家用 HIFU 设备每天处理 30 秒和 60 秒，连续 1 周，或每天处理 30 秒和 60 秒，连续 2 周，在三色染色后真皮厚度增加。HIFU 处理后 I 型和 III 型胶原和弹性蛋白的基因和蛋白表达增加，每天处理 30 秒和 60 秒，连续 1 周或每天处理 30 秒和 60 秒，连续 2 周。HIFU 处理后 MMP-1 和 TIMP-1 的基因和蛋白表达减少，每天处理 30 秒和 60 秒，连续 1 周或每天处理 30 秒和 60 秒，连续 2 周。
结论
家用 HIFU 设备可作为一种有效的皮肤紧致治疗方法。
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