Department of Paediatrics, Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal.
Department of General Practice and Emergency Medicine, Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal.
JNMA J Nepal Med Assoc. 2022 Nov 2;60(255):972-974. doi: 10.31729/jnma.7889.
Metronidazole belongs to the nitroimidazole group of antibiotics. It is used for the treatment of anaerobic and protozoal organisms. Its common side effects are nausea, vomiting, headache, and abdominal pain. Urine discolouration is one of the rare side effects of metronidazole. We report a case of 4-years-old male, a known case of Steroid resistant nephrotic syndrome; Focal Segmental Glomerulosclerosis type who developed reddish discolouration of urine following the introduction of oral metronidazole which reverted back to its usual colour within 24 hours of discontinuing metronidazole. With no evidence of other possible causes, urine discolouration was linked with the use of metronidazole. Urine discoloration as a side effect of metronidazole is rarely reported in the literature. This case report of the rare adverse effects of the commonly used drug can be of importance in the scientific community. Urine discolouration could be considered a side effect of metronidazole when there is no other obvious cause.
flagyl; hematuria; metronidazole; side effects of drugs.
甲硝唑属于硝基咪唑类抗生素。它用于治疗厌氧和原生动物生物体。其常见的副作用有恶心、呕吐、头痛和腹痛。尿液变色是甲硝唑的罕见副作用之一。我们报告了一例 4 岁男性，已知患有类固醇耐药性肾病综合征；局灶节段性肾小球硬化症患者，在口服甲硝唑后出现尿液变红，停用甲硝唑后 24 小时内尿液颜色恢复正常。由于没有其他可能原因的证据，将尿液变色与甲硝唑的使用联系起来。甲硝唑引起的尿液变色在文献中很少报道。本报告罕见的常用药物不良反应案例，在科学界可能具有重要意义。如果没有其他明显原因，可考虑将尿液变色作为甲硝唑的副作用。
灭滴灵；血尿；甲硝唑；药物副作用。
