School of Pharmaceutical Sciences, Lovely Professional University, Punjab-144411, India.
Curr Diabetes Rev. 2023;19(8):e270123213221. doi: 10.2174/1573399819666230127150328.
A diabetic foot ulcer is a chronic clinical manifestation of diabetes that exacerbates the condition of a patient and has a considerable socioeconomic impact. A diabetic foot ulcer (DFU) impacts around 25% of patients with diabetes mellitus at a certain point in their lives, and the underlying cause of the condition appears to be linked to neuropathic, ischaemic, and/or neuroischaemic pathologies. For the effective treatment of DFU, a variety of conventional treatments are used. However, in recent years, a range of innovative materials have been studied to bolster standard treatment tactics and promote the desired biological response by transcending the impediments of current wound healing approaches. Inorganic/organic hydrogel hybrids for tissue regeneration are among the most promising materials. This review article outlines the current treatment options for DFU, applications of hydrogel with an emphasis on wound healing, polymeric materials used to fabricate hydrogel, and the role of emerging technologies.
糖尿病足溃疡是糖尿病的一种慢性临床表现，会使患者病情恶化，对社会经济产生重大影响。大约 25%的糖尿病患者在其一生中的某个时刻会出现糖尿病足溃疡，其根本原因似乎与神经病变、缺血和/或神经缺血性病变有关。为了有效治疗 DFU，使用了多种常规治疗方法。然而，近年来，已经研究了一系列创新材料，以通过克服当前伤口愈合方法的障碍来增强标准治疗策略并促进所需的生物学反应。用于组织再生的无机/有机水凝胶混合物是最有前途的材料之一。本文综述了 DFU 的当前治疗选择，重点介绍了水凝胶在伤口愈合方面的应用、用于制造水凝胶的聚合物材料以及新兴技术的作用。
