血红素加氧酶-1：一种预测慢性鼻-鼻窦炎伴鼻息肉术后复发的新标志物。
HO-1: a new marker for predicting postoperative recurrence of CRSwNP.
作者信息
Gong Min-Jie, Wang Yu-Sheng, Lou Miao, Ma Rui-Ping, Hu Zhen-Zhen, Zheng Guo-Xi, Zhang Ya
机构信息
Department of Otolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
出版信息
Acta Otolaryngol. 2023 Feb;143(2):170-175. doi: 10.1080/00016489.2023.2168054. Epub 2023 Jan 27.
BACKGROUND
Chronic rhinosinusitis with polyps (CRSwNP) is a subtype of chronic rhinosinusitis and is highly prone to recurrence; therefore, it is urgent to find appropriate markers to predict recurrence of CRSwNP after surgery.
PURPOSE
We aim to investigate the expression of HO-1 in CRSwNP and assess its value of predicting postoperative recurrence of CRSwNP.
METHODS
We recruited 77 participants and collected clinical data of all. We use Immunohistochemical staining to determine the expression of HO-1 in tissues. We use Spearman correlation test to analyze the correlation between HO-1 positive cell count and clinical score, and ROC curve to assess the value of HO-1 positive cell count in predicting recurrence of CRSwNP.
RESULTS
HO-1 positive cells were macrophages and significantly increased in CRSwNP; HO-1 positive cell count was negatively correlated with preoperative SNOT-22 score; HO-1 can predict postoperative recurrence of CRSwNP, AUC = 0.80, = 0.004.
CONCLUSION
HO-1 is a biochemical marker of CRSwNP and can predict postoperative recurrence of CRSwNP.
背景
伴鼻息肉的慢性鼻-鼻窦炎（CRSwNP）是慢性鼻-鼻窦炎的一种亚型，极易复发；因此，迫切需要找到合适的标志物来预测CRSwNP术后复发情况。
目的
我们旨在研究HO-1在CRSwNP中的表达，并评估其预测CRSwNP术后复发的价值。
方法
我们招募了77名参与者并收集了所有人的临床数据。我们使用免疫组织化学染色来确定HO-1在组织中的表达。我们使用Spearman相关性检验来分析HO-1阳性细胞计数与临床评分之间的相关性，并使用ROC曲线来评估HO-1阳性细胞计数在预测CRSwNP复发中的价值。
结果
HO-1阳性细胞为巨噬细胞，在CRSwNP中显著增加；HO-1阳性细胞计数与术前SNOT-22评分呈负相关；HO-1可预测CRSwNP术后复发，AUC = 0.80，P = 0.004。
结论
HO-1是CRSwNP的一种生化标志物，可预测CRSwNP术后复发。
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