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多输注治疗中预测与预期剂量偏差的床边可视化工具。

Bedside visualisation tool for prediction of deviation from intended dosage in multi-infusion therapy.

机构信息

Department of Medical Technology and Clinical Physics, University Medical Centre Utrecht, GA Utrecht, The Netherlands.

Department of Neonatology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands.

出版信息

J Vasc Access. 2024 Jul;25(4):1121-1128. doi: 10.1177/11297298221146327. Epub 2023 Jan 27.

DOI:10.1177/11297298221146327
PMID:36705289
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11308313/
Abstract

BACKGROUND

In multi-infusion therapy, multiple infusion pumps are connected to one single vascular access point. Interaction between pressure changes from different pumps may result in temporary dosing errors, which can be very harmful to the patient. It is known that these dosing errors occur. However, clinicians tend to find it hard to estimate the order of magnitude of these errors.

METHODS

This research uses an existing mathematical model to create a bedside prediction tool that is able to provide clinicians with the dosing errors that will occur after flow rate changes in multi-infusion therapy. A panel of clinicians, consisting of both nurses and doctors, was formed, and, in order to assess the level of knowledge about dosing errors in multi-infusion, the panel was presented with four medication schedules in which a syringe exchange or change in flow rate took place. The panel was asked to predict the resulting dosing errors.

RESULTS

A prediction tool was developed that describes a two pump multi-infusion system and predicts dosing errors resulting from changing the flow rate at one pump. 44% of the panel members wrongly predicted the impact of changing the set flow of liquid A on the flow of liquid B that reaches the patient. Nobody was able to correctly predict the dosing deviation if a very small catheter was used. After the prediction tool was shown, the clinicians indicated they had a improved understanding of what deviations to expect and that the tool would be useful in understanding multi-infusion dosing errors.

CONCLUSIONS

Using the predictive tool to visualise the deviations from the set flow rate is an effective method to allow clinicians to gain insight in dosing errors in multi-infusion therapy. This knowledge can be used to better anticipate future dosing errors in clinical situations.

摘要

背景

在多输液治疗中,多个输液泵连接到一个单一的血管通路点。来自不同泵的压力变化之间的相互作用可能导致暂时的给药错误,这对患者可能非常有害。已知这些给药错误会发生。然而,临床医生往往发现很难估计这些错误的数量级。

方法

本研究使用现有的数学模型创建了一个床边预测工具,该工具能够为临床医生提供多输液治疗中流速变化后将发生的给药错误。组成了一个由护士和医生组成的临床医生小组,为了评估多输液中给药错误的知识水平,小组被提供了四个药物方案,其中发生了注射器更换或流速变化。小组被要求预测由此产生的给药错误。

结果

开发了一种预测工具,描述了一个双泵多输液系统,并预测了改变一个泵的流速时产生的给药错误。44%的小组成员错误地预测了改变液体 A 的设定流速对到达患者的液体 B 流量的影响。如果使用非常小的导管,没有人能够正确预测给药偏差。在展示了预测工具后,临床医生表示他们对预期的偏差有了更好的理解,并且该工具将有助于理解多输液给药错误。

结论

使用预测工具可视化设定流速的偏差是一种有效的方法,可以使临床医生深入了解多输液治疗中的给药错误。这种知识可用于更好地预测临床情况下未来的给药错误。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da2a/11308313/edfcf5e4eb89/10.1177_11297298221146327-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da2a/11308313/9e290badd926/10.1177_11297298221146327-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da2a/11308313/0f873968adbf/10.1177_11297298221146327-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da2a/11308313/76f8af6db77f/10.1177_11297298221146327-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da2a/11308313/edfcf5e4eb89/10.1177_11297298221146327-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da2a/11308313/9e290badd926/10.1177_11297298221146327-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da2a/11308313/0f873968adbf/10.1177_11297298221146327-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da2a/11308313/76f8af6db77f/10.1177_11297298221146327-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da2a/11308313/edfcf5e4eb89/10.1177_11297298221146327-fig4.jpg

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本文引用的文献

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Evaluation of a novel flow-controlled syringe infusion pump for precise and continuous drug delivery at low flow rates: a laboratory study.一种新型流量控制注射器输注泵的评估:在低流速下精确和连续药物输送的实验室研究。
Anaesthesia. 2019 Nov;74(11):1425-1431. doi: 10.1111/anae.14784. Epub 2019 Aug 2.
2
Analytical method for calculation of deviations from intended dosages during multi-infusion.多输液过程中预期剂量偏差计算的分析方法。
Biomed Eng Online. 2017 Jan 17;16(1):18. doi: 10.1186/s12938-016-0309-4.
3
In vitro comparison of two changeover methods for vasoactive drug infusion pumps: quick-change versus automated relay.
血管活性药物输注泵两种转换方法的体外比较:快速更换与自动中继。
Biomed Tech (Berl). 2015 Aug;60(4):377-80. doi: 10.1515/bmt-2014-0140.
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Flow variability and its physical causes in infusion technology: a systematic review of in vitro measurement and modeling studies.输液技术中的流量变异性及其物理成因:体外测量与建模研究的系统综述
Biomed Tech (Berl). 2015 Aug;60(4):277-300. doi: 10.1515/bmt-2014-0148.
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How physical infusion system parameters cause clinically relevant dose deviations after setpoint changes.设定值改变后,物理输注系统参数如何导致临床相关剂量偏差。
Biomed Tech (Berl). 2015 Aug;60(4):365-76. doi: 10.1515/bmt-2014-0139.
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Infusion system carrier flow perturbations and dead-volume: large effects on drug delivery in vitro and hemodynamic responses in a swine model.输液系统载体流动扰动与死体积:对猪模型体外药物递送及血流动力学反应有重大影响。
Anesth Analg. 2015 Jun;120(6):1255-63. doi: 10.1213/ANE.0000000000000654.
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Computer control of drug delivery by continuous intravenous infusion: bridging the gap between intended and actual drug delivery.计算机控制连续静脉输注给药:弥合预期与实际药物输送之间的差距。
Anesthesiology. 2015 Mar;122(3):647-58. doi: 10.1097/ALN.0000000000000519.
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A literature review on flow-rate variability in neonatal IV therapy.新生儿静脉输液治疗中流速变异性的文献综述。
Paediatr Anaesth. 2013 Jan;23(1):9-21. doi: 10.1111/pan.12039. Epub 2012 Oct 12.
9
[Major haemodynamic incident during continuous norepinephrine infusion: Beware of the infusion line. An avoidable postoperative hypertensive peak?].[持续输注去甲肾上腺素期间的重大血流动力学事件:谨防输液管路。术后高血压峰值是否可避免?]
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