Product Development Group Zurich, ETH Zurich, Zurich, Switzerland.
Department of Anaesthesia, University Children's Hospital Zurich, Zurich, Switzerland.
Anaesthesia. 2019 Nov;74(11):1425-1431. doi: 10.1111/anae.14784. Epub 2019 Aug 2.
Syringe infusion pumps are used for the administration of short-acting drugs in anaesthesia and critical care medicine, but are prone to flow irregularities at low flow rates. A flow-controlled syringe infusion pump using an integrated flow sensor for feedback control represents a new approach to overcoming these limitations. This study compares the performance of a prototype flow-controlled syringe pump both at start-up, and during vertical displacement manoeuvres, with that of a standard infusion syringe pump. The novel pump almost completely eliminated delays at start-up and flow irregularities during hydrostatic pressure changes. Related fluctuations in plasma drug concentration were minimised and the known disadvantages of standard syringe infusion pumps currently used in clinical practice were reduced. Besides providing fast start-up to steady-state flow and precise continuous drug delivery at low flow rates during hydrostatic pressure changes, the new pump offers the potential for the development of target-controlled infusion algorithms for short-acting cardiovascular and other drugs.
注射器输注泵用于麻醉和重症监护医学中的短效药物给药，但在低流速下容易出现流量不规则。使用集成流量传感器进行反馈控制的流量控制注射器输注泵代表了克服这些限制的一种新方法。本研究比较了在启动时和垂直位移操作期间，原型流量控制注射器泵与标准输注注射器泵的性能。新型泵几乎完全消除了启动时的延迟和静水压变化期间的流量不规则性。最小化了与血浆药物浓度相关的波动，并减少了目前临床实践中使用的标准注射器输注泵的已知缺点。除了在静水压变化期间提供快速从启动到稳定流量的启动和低流速下精确的连续药物输送外，新型泵还为开发用于短效心血管和其他药物的靶控输注算法提供了潜力。
