炎症性多发性神经病中抗周围神经组织抗体的临床意义

Clinical significance of antibodies against peripheral nerve tissue in inflammatory polyneuropathy.

作者信息

van Doorn P A, Brand A, Vermeulen M

机构信息

Department of Neurology, Academic Hospital Rotterdam-Dijkzigt, The Netherlands.

出版信息

Neurology. 1987 Nov;37(11):1798-802. doi: 10.1212/wnl.37.11.1798.

DOI:10.1212/wnl.37.11.1798

PMID:3670618

Abstract

With the use of a mixed hemagglutination test (MHT), circulating antibodies against human peripheral nerve tissue (PNT) were found in 22 of 38 patients with Guillain-Barré syndrome (GBS) or chronic relapsing demyelinating inflammatory polyneuropathy (CR-DIP). The antibodies were found in only 1 of 34 patients with polyneuropathy of other origin, and in 3 of 32 patients without polyneuropathy. The presence of antibodies was related to response to intravenous gamma globulin treatment in CR-DIP patients. Antibodies against PNT may be pathogenic.

摘要

采用混合血凝试验（MHT），在38例吉兰 - 巴雷综合征（GBS）或慢性复发性脱髓鞘性炎性多发性神经病（CR - DIP）患者中的22例检测到针对人周围神经组织（PNT）的循环抗体。在34例其他病因的多发性神经病患者中仅1例检测到该抗体，在32例无多发性神经病的患者中有3例检测到。抗体的存在与CR - DIP患者静脉注射丙种球蛋白治疗的反应相关。针对PNT的抗体可能具有致病性。