Department of Biomedical Sciences (DIBINEM), University of Bologna, Via Irnerio, 48, 40126, Bologna, Italy.
Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Adv Biol Regul. 2023 Jan;87:100955. doi: 10.1016/j.jbior.2023.100955. Epub 2023 Jan 21.
Aberrant signaling pathways regulating proliferation and differentiation of hematopoietic stem cells (HSCs) can contribute to disease pathogenesis and neoplastic growth. Phosphoinositides (PIs) are inositol phospholipids that are implicated in the regulation of critical signaling pathways: aberrant regulation of Phospholipase C (PLC) beta1, PLCgamma1 and the PI3K/Akt/mTOR pathway play essential roles in the pathogenesis of Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML).
异常信号通路调节造血干细胞（HSCs）的增殖和分化可能导致疾病发病机制和肿瘤生长。磷酯酰肌醇（PIs）是肌醇磷脂，参与调节关键信号通路：PLCβ1、PLCγ1和PI3K/Akt/mTOR 通路的异常调节在骨髓增生异常综合征（MDS）和急性髓系白血病（AML）的发病机制中起着重要作用。
