Microbiology Service, University Hospital Marqués de Valdecilla - IDIVAL, Santander, Spain.
Microbiology Service, University Hospital Marqués de Valdecilla - IDIVAL, Santander, Spain.
Enferm Infecc Microbiol Clin (Engl Ed). 2023 Nov;41(9):567-570. doi: 10.1016/j.eimce.2022.06.017. Epub 2023 Jan 25.
The aim was to investigate the in vitro activity of ceftobiprole and dalbavancin against a collection of coagulase-negative staphylococci (CoNS) isolates with reduced susceptibility to daptomycin or resistant to linezolid and/or glycopeptides.
A total of 228 CoNS were tested using the Vitek-2 AST-626 cards (bioMérieux) and MIC of daptomycin, linezolid, vancomycin and teicoplanin were confirmed by Etest Strips (bioMérieux). Susceptibility testing for ceftobiprole and dalbavancin were performed by CLSI broth microdilution methodology. Results were interpreted according to 2021 EUCAST clinical breakpoints.
Ceftobiprole and dalbavancin were active against 96.0% and 93.0% of CoNS, respectively, MIC were 2 and 0.125mg/L. MICs of ceptobiprole were higher against S. hominis and S. haemolyticus (MIC 4mg/L). Dalbavancin exhibited higher MICs against S. haemolyticus and CoNS with reduced susceptibility to daptomycin and resistant to teicoplanin.
Ceftobiprole and dalbavancin demonstrated a high in vitro activity against our collection of CoNS isolates.
本研究旨在探究头孢洛林和达巴万星对耐达霉素、利奈唑胺//或糖肽类药物敏感性降低或耐药的凝固酶阴性葡萄球菌（CoNS）分离株的体外活性。
采用 Vitek-2 AST-626 卡（生物梅里埃）检测 228 株 CoNS，并用 Etest 试条（生物梅里埃）确认达托霉素、利奈唑胺、万古霉素和替考拉宁的 MIC。头孢洛林和达巴万星的药敏试验采用 CLSI 肉汤微量稀释法进行。结果根据 2021 年 EUCAST 临床折点进行解释。
头孢洛林和达巴万星对 CoNS 的活性分别为 96.0%和 93.0%，MIC 分别为 2mg/L 和 0.125mg/L。头孢洛林对人葡萄球菌和溶血葡萄球菌的 MIC 较高（MIC4mg/L）。达巴万星对溶血葡萄球菌和耐达霉素、替考拉宁的 CoNS 的 MIC 较高。
头孢洛林和达巴万星对本研究中收集的 CoNS 分离株表现出很高的体外活性。
