Ward Natalie C, Watts Gerald F, Bishop Warrick, Colquhoun David, Hamilton-Craig Christian, Hare David L, Kangaharan Nadarajah, Kostner Karam M, Kritharides Leonard, O'Brien Richard, Mori Trevor A, Nestel Paul J, Nicholls Stephen J, Psaltis Peter J, Raffoul Natalie, White Harvey D, Sullivan David R
Dobney Hypertension Centre, Medical School, University of Western Australia, Perth, WA, Australia.
Medical School, University of Western Australia, Perth, WA, Australia; Lipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, Perth, WA, Australia.
Heart Lung Circ. 2023 Mar;32(3):287-296. doi: 10.1016/j.hlc.2022.11.015. Epub 2023 Jan 25.
This position statement provides guidance to cardiologists and related specialists on the management of adult patients with elevated lipoprotein(a) [Lp(a)]. Elevated Lp(a) is an independent and causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valve disease (CAVD). While circulating Lp(a) levels are largely determined by ancestry, they are also influenced by ethnicity, hormones, renal function, and acute inflammatory events, such that measurement should be done after accounting for these factors. Further, circulating Lp(a) concentrations should be estimated using an apo(a)-isoform independent assay that employs appropriate calibrators and reports the results in molar units (nmol/L). Selective screening strategies of high-risk patients are recommended, but universal screening of the population is currently not advised. Testing for elevated Lp(a) is recommended in all patients with premature ASCVD and those considered to be at intermediate-to-high risk of ASCVD. Elevated Lp(a) should be employed to assess and stratify risk and to enable a decision on initiation or intensification of preventative treatments, such as cholesterol lowering therapy. In adult patients with elevated Lp(a) at intermediate-to-high risk of ASCVD, absolute risk should be reduced by addressing all modifiable behavioural, lifestyle, psychosocial and clinical risk factors, including maximising cholesterol-lowering with statin and ezetimibe and, where appropriate, PCSK9 inhibitors. Apheresis should be considered in patients with progressive ASCVD. New ribonucleic acid (RNA)-based therapies which directly lower Lp(a) are undergoing clinical trials.
本立场声明为心脏病专家和相关专科医生提供了关于脂蛋白(a)[Lp(a)]升高的成年患者管理的指导。Lp(a)升高是动脉粥样硬化性心血管疾病(ASCVD)和钙化性主动脉瓣疾病(CAVD)的独立病因性危险因素。虽然循环Lp(a)水平在很大程度上由遗传决定,但它们也受种族、激素、肾功能和急性炎症事件的影响,因此在考虑这些因素后应进行测量。此外,循环Lp(a)浓度应使用不依赖载脂蛋白(a)异构体的检测方法进行估算,该方法采用适当的校准物并以摩尔单位(nmol/L)报告结果。建议对高危患者采取选择性筛查策略,但目前不建议对普通人群进行普遍筛查。建议对所有早发性ASCVD患者以及被认为有中度至高度ASCVD风险的患者进行Lp(a)升高检测。应利用Lp(a)升高来评估风险并进行分层,以便决定是否开始或强化预防性治疗,如降胆固醇治疗。在有中度至高度ASCVD风险且Lp(a)升高的成年患者中,应通过解决所有可改变的行为、生活方式、心理社会和临床风险因素来降低绝对风险,包括最大限度地使用他汀类药物和依折麦布降低胆固醇,以及在适当情况下使用前蛋白转化酶枯草溶菌素9(PCSK9)抑制剂。对于进展性ASCVD患者应考虑进行血液成分单采。直接降低Lp(a)的新型基于核糖核酸(RNA)的疗法正在进行临床试验。
Curr Atheroscler Rep. 2019-3-7
Cardiovasc Drugs Ther. 2019-12
Nutr Metab Cardiovasc Dis. 2023-10
South Med J. 2024-4
Front Cardiovasc Med. 2025-2-14