Echocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Road, Chaoyang District, Beijing, China.
Maternal-Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
BMC Cardiovasc Disord. 2023 Jan 27;23(1):52. doi: 10.1186/s12872-022-02981-3.
Current studies have suggested that fetal congenital heart diseases (CHDs) are caused by various factors. However, few data in this field is available in China. This study aimed to detect associated factors of prenatally diagnosed fetal CHD in a large sample in China.
Pregnant women who underwent fetal echocardiography were recruited in our hospital between May 2018 and September 2019. The maternal sociodemographic and lifestyle characteristics and some fetal factors were obtained. We used forward stepwise logistic regression analysis to assess risk of fetal CHD associated with various factors.
A total of 5024 subjects were enrolled, of whom 875 had CHD fetuses. Among the fetal CHD group (N = 875), critical CHDs account for 27%, of which Tetralogy of Fallot is the most (7.1%), followed by coarctation of aorta (4.0%), double-outlet right ventricle (2.9%). The forward stepwise logistic regression models revealed that history of spontaneous abortion (OR = 1.59, 95% CI 1.33-1.91, P = 0.000), upper respiratory tract infection during early pregnancy (OR = 1.30, 95% CI 1.04-1.62, P = 0.020), mental stress during early pregnancy (OR = 2.37, 95% CI 1.15-4.91, P = 0.020), single umbilical artery (OR = 2.30, 95% CI 1.18-4.51, P = 0.015), and paternal smoking (OR = 1.21, 95% CI 1.02-1.44, P = 0.027) are positively associated with an increased risk of fetal CHD.
We identified several factors positively associated with fetal CHD. These findings suggest that it is important to strengthen healthcare and prenatal counseling for women with these factors.
目前的研究表明，胎儿先天性心脏病（CHD）是由多种因素引起的。然而，中国在这一领域的数据很少。本研究旨在检测中国大样本中产前诊断胎儿 CHD 的相关因素。
本研究纳入了 2018 年 5 月至 2019 年 9 月在我院行胎儿超声心动图检查的孕妇。获取了孕妇的社会人口统计学和生活方式特征以及一些胎儿因素。我们使用逐步向前逻辑回归分析来评估与各种因素相关的胎儿 CHD 风险。
共纳入 5024 例受试者，其中 875 例胎儿患有 CHD。在胎儿 CHD 组（N=875）中，严重 CHD 占 27%，其中法洛四联症最常见（7.1%），其次是主动脉缩窄（4.0%），双出口右心室（2.9%）。逐步向前逻辑回归模型显示，自然流产史（OR=1.59，95%CI 1.33-1.91，P=0.000）、妊娠早期上呼吸道感染（OR=1.30，95%CI 1.04-1.62，P=0.020）、妊娠早期精神压力（OR=2.37，95%CI 1.15-4.91，P=0.020）、单脐动脉（OR=2.30，95%CI 1.18-4.51，P=0.015）和父亲吸烟（OR=1.21，95%CI 1.02-1.44，P=0.027）与胎儿 CHD 风险增加呈正相关。
我们确定了一些与胎儿 CHD 呈正相关的因素。这些发现表明，加强对这些因素的孕妇保健和产前咨询非常重要。
