Kensington Eye Institute, Toronto, Ontario, Canada.
Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.
Acta Ophthalmol. 2023 Aug;101(5):568-574. doi: 10.1111/aos.15639. Epub 2023 Jan 27.
To evaluate the relationship between subjective (slit lamp examination [SLE]) and objective (densitometry) measurements of corneal haze after accelerated corneal crosslinking (aCXL), assess the relationship between densitometry and corrected distance visual acuity (CDVA), and determine the effect of baseline characteristics on densitometry after aCXL in eyes with progressive keratoconus and other ectasias.
Kensington Eye Institute and Bochner Eye Institute, Toronto, Canada.
Retrospective analysis of a prospective interventional cohort study.
Scheimpflug-derived corneal densitometry, CDVA, maximum keratometry (K ), and central corneal thickness were measured preoperatively and up to 1 year after aCXL, and post-operative haze was estimated with SLE (n = 483 eyes). A random effect model was used to examine the relationship between post-operative subjective haze with SLE and densitometry. Linear mixed models were used to examine the relationship between densitometry, pre-operative baseline characteristics, and CDVA.
There was a significant association between subjective haze with SLE and densitometry (p < 0.001). There was a significant relationship between CDVA and densitometry: for every 10 GSUs of increased densitometry in the 0-2 mm zone, CDVA worsened by approximately half a Snellen line (p < 0.001). Age and pre-operative K were significant predictors of densitometry. For every 10 years of age, densitometry increased by 0.68 GSUs (95% CI [0.27 to 1.07], p < 0.001). For every 10 D of increased preoperative K , densitometry increased by 0.69 GSUs (95% CI [0.41 to 0.98], p < 0.001).
Subjective haze after aCXL estimated with SLE, is significantly associated with densitometry. Increased densitometry after aCXL is associated with a reduction in CDVA.
评估加速角膜交联（aCXL）后角膜混浊的主观（裂隙灯检查[SLE]）和客观（密度测定）测量之间的关系，评估密度测定与矫正距离视力（CDVA）之间的关系，并确定基线特征对进展性圆锥角膜和其他扩张性疾病患者 aCXL 后密度测定的影响。
加拿大多伦多肯辛顿眼科研究所和博纳尼眼科研究所。
前瞻性干预队列研究的回顾性分析。
在 aCXL 术前和术后 1 年，使用 Scheimpflug 衍生的角膜密度计、CDVA、最大角膜曲率（K）和中央角膜厚度进行测量，并使用 SLE 评估术后混浊（n=483 只眼）。使用随机效应模型检查术后 SLE 主观混浊与密度测定之间的关系。使用线性混合模型检查密度测定、术前基线特征和 CDVA 之间的关系。
SLE 主观混浊与密度测定之间存在显著相关性（p<0.001）。CDVA 与密度测定之间存在显著关系：在 0-2mm 区域内，每增加 10 个灰度单位（GSUs）的密度，CDVA 就会恶化大约半行 Snellen 视力表（p<0.001）。年龄和术前 K 是密度测定的重要预测因素。每增加 10 岁，密度增加 0.68 GSUs（95%CI [0.27 至 1.07]，p<0.001）。术前 K 每增加 10D，密度增加 0.69 GSUs（95%CI [0.41 至 0.98]，p<0.001）。
SLE 评估的 aCXL 后主观混浊与密度测定显著相关。aCXL 后密度增加与 CDVA 降低相关。
