Li Cheng, Gong Peiwei, Chao Mianran, Li Juan, Yang Liyan, Huang Yan, Wang Dandan, Liu Jianxi, Liu Zhe
The Key Laboratory of Life-Organic Analysis, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong, 273165, P. R. China.
State Key Laboratory of Solidification Processing, Center of Advanced Lubrication and Seal Materials, School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an, 710072, P. R. China.
Adv Healthc Mater. 2023 May;12(12):e2203245. doi: 10.1002/adhm.202203245. Epub 2023 Feb 5.
Osteoarthritis (OA) is associated with lubrication failure of articular cartilage and severe inflammatory response of joint capsule. Synergistic therapy combining joint lubrication and anti-inflammation emerges as a novel treatment of OA. In this study, bioinspired by ultralow friction of natural articular synovial fluid and mussel adhesion chemistry, a biomimetic nanosystem with dual functions of enhanced lubrication and stimuli-responsive drug release is developed. A dopamine mediated strategy realizes one step biomimetic grafting of hyaluronic acid (HA) on fluorinated graphene. The polymer modified sheets exhibit highly efficient near-infrared absorption, and show steady lubrication with a long time under various working conditions, in which the coefficient of friction is reduced by 75% compared to H O. Diclofenac sodium (DS) with a high loading capacity of 29.2% is controllably loaded, and responsive and sustained drug release is adjusted by near-infrared light. Cell experiments reveal that the lubricating nanosystem is taken up by endocytosis, and anti-inflammation results confirm that the nanosystem inhibits osteoarthritis deterioration by upregulating cartilage anabolic gene and downregulating catabolic proteases and pain-related gene. This work proposes a promising biomimetic approach to integrate polymer modified fluorinated graphene as a dual-functional nanosystem for effective synergistic therapy of OA.
骨关节炎（OA）与关节软骨润滑失效及关节囊严重炎症反应相关。联合关节润滑与抗炎的协同疗法成为OA的一种新型治疗方法。在本研究中，受天然关节滑液的超低摩擦和贻贝粘附化学的启发，开发了一种具有增强润滑和刺激响应药物释放双重功能的仿生纳米系统。多巴胺介导的策略实现了透明质酸（HA）在氟化石墨烯上的一步仿生接枝。聚合物改性片材表现出高效的近红外吸收，并在各种工作条件下长时间显示出稳定的润滑性能，其中与水相比，摩擦系数降低了75%。可控制地负载了高负载量为29.2%的双氯芬酸钠（DS），并通过近红外光调节响应性和持续性药物释放。细胞实验表明，润滑纳米系统通过内吞作用被摄取，抗炎结果证实该纳米系统通过上调软骨合成代谢基因和下调分解代谢蛋白酶及疼痛相关基因来抑制骨关节炎的恶化。这项工作提出了一种有前景的仿生方法，将聚合物改性氟化石墨烯整合为双功能纳米系统，用于OA的有效协同治疗。
