基于计算机的鉴定靶向 PPARα/γ 的 microRNAs：针对 SARS-CoV-2 感染的有前景的治疗方法。
In silico identification of microRNAs targeting the PPARα/γ: promising therapeutics for SARS-CoV‑2 infection.
机构信息
Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi Arabia.
Department of Microbiology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
出版信息
Biotechnol Genet Eng Rev. 2023 Oct;39(2):859-870. doi: 10.1080/02648725.2022.2163867. Epub 2023 Jan 28.
The SARS-CoV-2 lifecycle is dependent on the host metabolism machinery. It upregulates the PPARα and PPARγ genes in lipid metabolism, which supports the essential viral replication complex including lipid rafts and palmitoylation of viral protein. The use of PPAR ligands in SARS-CoV-2 infection may have positive effects by preventing cytokine storm and the ensuing inflammatory cascade. The inhibition of PPARα and PPARγ genes may alter the metabolism and may disrupt the lifecycle of SARS-CoV-2 and COVID-19 progression. In the present work, we have identified possible miRNAs targeting PPARα and PPARγ in search of modulators of PPARα and PPARγ genes expression. The identified miRNAs could possibly be viewed as new therapeutic targets against COVID-19 infection.
SARS-CoV-2 的生命周期依赖于宿主代谢机制。它上调脂质代谢中的 PPARα 和 PPARγ 基因，为包括脂筏和病毒蛋白棕榈酰化在内的基本病毒复制复合物提供支持。在 SARS-CoV-2 感染中使用 PPAR 配体可能通过预防细胞因子风暴和随之而来的炎症级联反应产生积极影响。抑制 PPARα 和 PPARγ 基因可能会改变代谢，并破坏 SARS-CoV-2 和 COVID-19 进展的生命周期。在本工作中，我们已经鉴定了针对 PPARα 和 PPARγ 的可能 miRNA，以寻找 PPARα 和 PPARγ 基因表达的调节剂。鉴定的 miRNA 可能被视为针对 COVID-19 感染的新治疗靶点。
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