Caley L R, Zagoya C, Duckstein F, White H, Shimmin D, Jones A M, Barrett J, Whitehouse J L, Floto R A, Mainz J G, Peckham D G
Leeds Institute of Medical Research at St James's University Hospital, University of Leeds, Leeds, United Kingdom.
Brandenburg Medical School, University Hospital. Klinikum Westbrandenburg, Brandenburg an der Havel, Germany.
J Cyst Fibros. 2023 Mar;22(2):275-281. doi: 10.1016/j.jcf.2023.01.010. Epub 2023 Jan 27.
Individuals with diabetes mellitus (DM) are known to frequently experience gastrointestinal (GI) symptoms. In contrast, the impact of cystic fibrosis-related diabetes (CFRD) on accentuating GI symptoms in people with cystic fibrosis (pwCF) is unknown. We sought to examine this.
Abdominal symptoms were measured using the validated CF-specific GI symptom questionnaire - CFAbd-Score© - as part of a multicentre cohort study in pancreatic insufficient adults with CF, not on cystic fibrosis transmembrane conductance regulator (CFTR) modulators. The CFAbd-Score total score (0-100pts), its 5 domains, alongside nine specific GI symptoms associated with DM, were compared between the CFRD and non-CFRD groups.
27 (31%) and 61 (69%) participants with CF were recruited in the CFRD and non-CFRD groups respectively. Total CFAbd-Score and the two domains: gastroesophageal reflux disease and disorders of appetite were significantly higher in the CFRD group compared to the non-CFRD group (p<0.05), with the mean total CFAbd-Score being 25.4 ± 2.5 and 18.4 ± 1.5 in the CFRD and non-CFRD groups respectively. Among the nine GI symptoms commonly reported as elevated in DM, bloating and nausea were significantly more common in individuals with CFRD compared to those without (p<0.05).
Individuals with CFRD overall, have a higher GI symptom burden, according to CFAbd-Scores. Specifically, they experience significantly more bloating and nausea. Close monitoring and further research is needed to better understand and manage GI symptoms in this group.
糖尿病（DM）患者常出现胃肠道（GI）症状。相比之下，囊性纤维化相关糖尿病（CFRD）对囊性纤维化患者（pwCF）胃肠道症状加重的影响尚不清楚。我们试图对此进行研究。
在一项针对胰腺功能不全的成年CF患者（未使用囊性纤维化跨膜传导调节因子（CFTR）调节剂）的多中心队列研究中，使用经过验证的CF特异性胃肠道症状问卷——CFAbd-Score©来测量腹部症状。比较了CFRD组和非CFRD组的CFAbd-Score总分（0 - 100分）、其5个领域以及与糖尿病相关的9种特定胃肠道症状。
CFRD组和非CFRD组分别招募了27名（31%）和61名（69%）CF患者。与非CFRD组相比，CFRD组的CFAbd-Score总分以及胃食管反流病和食欲障碍这两个领域显著更高（p<0.05），CFRD组和非CFRD组的平均CFAbd-Score总分分别为25.4±2.5和18.4±1.5。在通常报告在糖尿病中升高的9种胃肠道症状中，CFRD患者腹胀和恶心的发生率明显高于非CFRD患者（p<0.05）。
根据CFAbd-Score评分，CFRD患者总体上胃肠道症状负担更高。具体而言，他们腹胀和恶心的症状明显更多。需要密切监测和进一步研究，以更好地了解和管理该群体的胃肠道症状。
