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聚丙烯/(十六烷基)三甲基溴化铵复合材料对新型冠状病毒肺炎的抗病毒能力

Antiviral capacity of polypropylene/(1-Hexadecyl) trimethyl-ammonium bromide composites against COVID-19.

作者信息

Guerrero-Bermea Cynthia, Rodríguez Fuentes Nayeli, Cervantes-Uc José Manuel, Alcántara Quintana Luz Eugenia, Díaz-Barriga Fernando, Pérez-Vázquez Francisco, González-Palomo Karen, Uribe-Calderon Jorge Alonso

机构信息

Centro de Investigación Científica de Yucatán, A.C. Unidad de Materiales Mérida Mexico.

CONACYT-Centro de Investigación Científica de Yucatán, A.C. Unidad de Materiales Mérida Mexico.

出版信息

Polym Eng Sci. 2022 Dec;62(12):4129-4135. doi: 10.1002/pen.26172. Epub 2022 Oct 14.

Abstract

During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, scientists from different areas are looking for alternatives to fight it. SARS-CoV-2, the cause of the infectious respiratory disease COVID-19, is mainly transmitted through direct or indirect contact with infected respiratory droplets. The integrity of the virus structure is crucial for its viability to attack human cells. Quaternary ammonium salts are characterized by having antiviral capabilities which alter or destroy the structure of the viral capsid. In this work, polypropylene (PP)/(1-Hexadecyl) trimethyl-ammonium bromide (CTAB) composites have been prepared in order to create an antiviral material. The composites were melt processed and blown to produce thin films. The CTAB content on the antiviral effect was evaluated using antibodies and serum from infected patients with the SARS-CoV-2 virus. In addition, the mechanical and thermal properties of blown films were investigated, and CTAB release kinetics from the films was followed by UV-Vis. The results indicate that the virus tends to remain less on the polymer surface by increasing the amount of CTAB in the PP matrix.

摘要

在严重急性呼吸综合征冠状病毒2(SARS-CoV-2)大流行期间,来自不同领域的科学家正在寻找对抗它的替代方法。SARS-CoV-2是传染性呼吸道疾病COVID-19的病原体,主要通过直接或间接接触受感染的呼吸道飞沫传播。病毒结构的完整性对其攻击人类细胞的生存能力至关重要。季铵盐的特点是具有抗病毒能力,可改变或破坏病毒衣壳的结构。在这项工作中,制备了聚丙烯(PP)/(1-十六烷基)三甲基溴化铵(CTAB)复合材料,以制造一种抗病毒材料。对复合材料进行熔融加工并吹塑以制备薄膜。使用来自感染SARS-CoV-2病毒患者的抗体和血清评估CTAB含量对抗病毒效果的影响。此外,研究了吹塑薄膜的机械和热性能,并通过紫外可见光谱跟踪CTAB从薄膜中的释放动力学。结果表明,通过增加PP基体中CTAB的含量,病毒在聚合物表面的残留量往往会减少。

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