一个动态目标：降低病毒载量抑制切点对实现艾滋病流行控制目标进展的影响
A Moving Target: Impacts of Lowering Viral Load Suppression Cutpoints on Progress Towards HIV Epidemic Control Goals.
作者信息
Rosen Joseph G, Reynolds Steven J, Galiwango Ronald M, Kigozi Godfrey, Quinn Thomas C, Ratmann Oliver, Ndyanabo Anthony, Nelson Lisa J, Nakigozi Gertrude, Nalugemwa Margaret, Rucinski Katherine B, Kennedy Caitlin E, Chang Larry W, Kagaayi Joseph, Serwadda David, Grabowski M Kate
机构信息
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Rakai Health Sciences Program, Entebbe, Uganda.
出版信息
medRxiv. 2023 Jan 20:2023.01.19.23284804. doi: 10.1101/2023.01.19.23284804.
Redefining viral load suppression (VLS) using lower cutpoints could impact progress towards the UNAIDS 95-95-95 targets. We assessed impacts of lowering the VLS cutpoint on achieving the 95-95-95 VLS target in the Rakai Community Cohort Study. Population VLS fell from 86% to 84% and 76%, respectively, after lowering VLS cutpoints from <1,000 to <200 and <50 copies/mL. The fraction of viremic persons increased by 17% after lowering the VLS cutpoint from <1,000 to <200 copies/mL.
使用更低的切点重新定义病毒载量抑制（VLS）可能会影响实现联合国艾滋病规划署95-95-95目标的进程。我们在拉凯社区队列研究中评估了降低VLS切点对实现95-95-95 VLS目标的影响。将VLS切点从<1000拷贝/毫升降至<200拷贝/毫升和<50拷贝/毫升后，总体人群的VLS分别从86%降至84%和76%。将VLS切点从<1000拷贝/毫升降至<200拷贝/毫升后，病毒血症患者的比例增加了17%。
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