Genç E, Hizal A, Eroğlu L
Department of Pharmacology, Istanbul Medical Faculty, University of Istanbul, Capa, Turkey.
Pol J Pharmacol Pharm. 1987 Jan-Feb;39(1):41-5.
The effects of long term (10 days) treatment of lithium and naloxone on HVA levels of striatum, hypothalamus and frontal cortex in rats were investigated. Lithium (400 mg/l in drinking water) itself had no effect on HVA levels of any region. Naloxone (2 mg/kg) treatment caused significant increases in the levels of HVA in hypothalamus and striatum and lithium cotreatment prevented the effect of naloxone. Neither of those were observed in the frontal cortical region.
研究了锂和纳洛酮长期（10天）治疗对大鼠纹状体、下丘脑和额叶皮质中高香草酸（HVA）水平的影响。锂（饮用水中400毫克/升）本身对任何区域的HVA水平均无影响。纳洛酮（2毫克/千克）治疗导致下丘脑和纹状体中HVA水平显著升高，而锂联合治疗可阻止纳洛酮的这一作用。在额叶皮质区域未观察到上述任何一种情况。
