Sansone M, Renzi P, Vetulani J
Istituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy.
Pol J Pharmacol Pharm. 1987 Jan-Feb;39(1):75-9.
The disrupting action on avoidance responses, exerted by diazepam given during shuttle-box training (5 mg/kg before each session), was abolished by a pretreatment with the drug (5 mg/kg) for five days. Similarly, avoidance depression, produced by diazepam in trained mice, was prevented by a pretreatment with five daily doses and was attenuated by previous administration of three daily injections or even of a single dose of the drug. The results demonstrate that tolerance rapidly develops to diazepam-induced avoidance depression, as to other behavioral actions of benzodiazepines.
在穿梭箱训练期间给予地西泮（每次训练前5毫克/千克）对回避反应的干扰作用，可通过该药（5毫克/千克）预处理五天而消除。同样，地西泮在受过训练的小鼠中产生的回避抑制，可通过每日五次剂量的预处理来预防，并因先前给予三次每日注射甚至单次剂量的该药而减弱。结果表明，与苯二氮䓬类药物的其他行为作用一样，对其引起的回避抑制耐受性迅速形成。
