训练期间给予苯二氮䓬类药物和吗啡组合可改善小鼠穿梭箱实验表现。
Improvement of shuttle-box performance of mice by combinations of benzodiazepines and morphine given during training.
作者信息
Sansone M, Castellano C, Vetulani J
出版信息
Arch Int Pharmacodyn Ther. 1977 Nov;230(1):83-91.
PMID:603312
Abstract
Chlorodiazepoxide, diazepam and morphine, given alone or in combination, were tested in naive mice subjected to five 100-trial avoidance sessions in the shuttle-box. When given alone before each training session all three drugs improved avoidance behaviour. However, facilitation of avoidance responding was much more evident when either benzodiazepine derivative was given in combination with morphine.
摘要
将氯氮卓、地西泮和吗啡单独使用或联合使用，在穿梭箱中对未经训练的小鼠进行了5次每次100次试验的回避训练测试。在每次训练前单独给药时，这三种药物均能改善回避行为。然而，当任何一种苯二氮卓衍生物与吗啡联合使用时，对回避反应的促进作用更为明显。
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