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训练期间给予苯二氮䓬类药物和吗啡组合可改善小鼠穿梭箱实验表现。

Improvement of shuttle-box performance of mice by combinations of benzodiazepines and morphine given during training.

作者信息

Sansone M, Castellano C, Vetulani J

出版信息

Arch Int Pharmacodyn Ther. 1977 Nov;230(1):83-91.

PMID:603312
Abstract

Chlorodiazepoxide, diazepam and morphine, given alone or in combination, were tested in naive mice subjected to five 100-trial avoidance sessions in the shuttle-box. When given alone before each training session all three drugs improved avoidance behaviour. However, facilitation of avoidance responding was much more evident when either benzodiazepine derivative was given in combination with morphine.

摘要

将氯氮卓、地西泮和吗啡单独使用或联合使用,在穿梭箱中对未经训练的小鼠进行了5次每次100次试验的回避训练测试。在每次训练前单独给药时,这三种药物均能改善回避行为。然而,当任何一种苯二氮卓衍生物与吗啡联合使用时,对回避反应的促进作用更为明显。

相似文献

1
Improvement of shuttle-box performance of mice by combinations of benzodiazepines and morphine given during training.训练期间给予苯二氮䓬类药物和吗啡组合可改善小鼠穿梭箱实验表现。
Arch Int Pharmacodyn Ther. 1977 Nov;230(1):83-91.
2
Facilitation of avoidance behavior by chlordiazepoxide and chlordiazepoxide-amphetamine combination: effect on performance.氯氮卓及氯氮卓-苯丙胺组合对回避行为的促进作用:对行为表现的影响
Pol J Pharmacol Pharm. 1980 Mar-Apr;32(2):125-31.
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Effects of chlordiazepoxide-scopolamine combinations on shuttle-box avoidance performance of mice.氯氮卓-东莨菪碱组合对小鼠穿梭箱回避行为的影响。
Arch Int Pharmacodyn Ther. 1978 Sep;235(1):93-102.
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Effects of chlordiazepoxide, CNS stimulants and their combinations on avoidance behaviour in mice.氯氮卓、中枢神经系统兴奋剂及其组合对小鼠回避行为的影响。
Arch Int Pharmacodyn Ther. 1975 Jun;215(2):190-6.
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Tolerance to diazepam-induced avoidance depression in mice.小鼠对安定诱导的回避性抑郁的耐受性
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Facilitation of avoidance behaviour by chlordiazepoxide-morphine combinations in reserpinzed mice.利血平化小鼠中氯氮卓-吗啡组合对回避行为的促进作用。
Pharmacol Res Commun. 1978 May;10(5):479-85. doi: 10.1016/s0031-6989(78)80038-1.
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Facilitation of avoidance learning by chlordiazepoxide-amphetamine combinations in mice.氯氮卓 - 苯丙胺组合对小鼠回避学习的促进作用。
Psychopharmacologia. 1975;41(2):117-21. doi: 10.1007/BF00421067.
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Effects of chlordiazepoxide, amitriptyline, imipramine, and their combinations on avoidance behaviour in mice.氯氮卓、阿米替林、丙咪嗪及其组合对小鼠回避行为的影响。
Psychopharmacology (Berl). 1978 Oct 31;59(2):151-5. doi: 10.1007/BF00427749.
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Effects of chlordiazepoxide-morphine combinations on spontaneous locomotor activity in three inbred strains of mice.氯氮卓 - 吗啡组合对三种近交系小鼠自发运动活性的影响。
Arch Int Pharmacodyn Ther. 1980 Sep;247(1):71-5.
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Benzodiazepines and amphetamine on avoidance behaviour in mice.苯二氮䓬类药物和苯丙胺对小鼠回避行为的影响。
Arch Int Pharmacodyn Ther. 1975 Nov;218(1):125-32.

引用本文的文献

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Avoidance facilitation by chlordiazepoxide-amphetamine combinations in mice: effect of alpha-methyl-p-tyrosine.氯氮卓-苯丙胺组合对小鼠回避行为的促进作用:α-甲基对酪氨酸的影响
Psychopharmacology (Berl). 1981;75(1):22-4. doi: 10.1007/BF00433495.
2
Enhancement by chlordiazepoxide of the anticholinergic-induced locomotor stimulation in mice.氯氮卓增强小鼠抗胆碱能药物诱导的运动兴奋作用。
Psychopharmacology (Berl). 1979 Aug 8;64(2):181-4. doi: 10.1007/BF00496059.