间溴苯基和对溴苯基琥珀酰亚胺的N-甲基吡啶基衍生物的合成及其抗惊厥特性
Synthesis and anticonvulsant properties of N-methylpyridyl derivatives of m- and p-bromophenylsuccinimides.
作者信息
Zejc A, Obniska J, Chojnacka-Wójcik E, Tatarczyńska E, Wiczyńska B
机构信息
Department of Pharmaceutical Chemistry, Medical Academy, Kraków, Poland.
出版信息
Pol J Pharmacol Pharm. 1987 Jan-Feb;39(1):91-5.
PMID:3671189
Abstract
The reaction of m- or p-bromophenylsuccinic acids with 2-aminomethylpyridines yielded respective N-methylpyridylimides 1-8. Only compounds 1 and 6 show anticonvulsant activity in the pentetrazole and electric seizures tests, but their therapeutic index is inferior to that of ethosuximide and valproic acid.
摘要
间溴苯基琥珀酸或对溴苯基琥珀酸与2-氨甲基吡啶反应分别生成相应的N-甲基吡啶酰亚胺1-8。仅化合物1和6在戊四氮和电惊厥试验中显示出抗惊厥活性，但其治疗指数低于乙琥胺和丙戊酸。
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