Athanasiadis Markos, Masserini Stefano, Yuan Li, Fetterhoff Dustin, Leutgeb Jill K, Leutgeb Stefan, Leibold Christian
Albert-Ludwigs-Universität Freiburg, Fakultät für Biologie & Bernstein Center Freiburg, 79104 Freiburg, Germany.
Universität Bremen, Fachbereich Physik, 28334 Bremen, Germany.
bioRxiv. 2023 Jan 9:2023.01.09.523199. doi: 10.1101/2023.01.09.523199.
Remembering what just happened is a crucial prerequisite to form long-term memories but also for establishing and maintaining working memory. So far there is no general agreement about cortical mechanisms that support short-term memory. Using a classifier-based decoding approach, we report that hippocampal activity during few sparsely distributed brief time intervals contains information about the previous sensory motor experience of rodents. These intervals are characterized by only a small increase of firing rate of only a few neurons. These low-rate predictive patterns are present in both working memory and non-working memory tasks, in two rodent species, rats and Mongolian gerbils, are strongly reduced for rats with medial entorhinal cortex lesions, and depend on the familiarity of the sensory-motor context.
记住刚刚发生的事情是形成长期记忆的关键前提，也是建立和维持工作记忆的关键前提。到目前为止，对于支持短期记忆的皮层机制尚无普遍共识。我们采用基于分类器的解码方法报告称，在少数稀疏分布的短暂时间间隔内，海马体活动包含有关啮齿动物先前感觉运动体验的信息。这些时间间隔的特征是只有少数神经元的放电率略有增加。这些低放电率预测模式在工作记忆和非工作记忆任务中均存在，在两种啮齿动物（大鼠和蒙古沙鼠）中，内侧内嗅皮层损伤的大鼠中这种模式会大幅减少，并且依赖于感觉运动背景的熟悉程度。
