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睡眠剥夺分子反应的个体发生。

Ontogenesis of the molecular response to sleep loss.

作者信息

Muheim Christine M, Ford Kaitlyn, Medina Elizabeth, Singletary Kristan, Peixoto Lucia, Frank Marcos G

机构信息

Washington State University Spokane, Department of Translational Medicine and Physiology, Sleep and Performance Research Center, Elson S. Floyd College of Medicine, Pharmaceutical and Biomedical Science Building 230, 412 E. Spokane Falls Blvd., Spokane WA 99202, USA.

WSU Health Sciences Spokane, Steve Gleason Institute for Neuroscience, 412 E. Spokane Falls Blvd., Spokane, WA 99202, USA.

出版信息

bioRxiv. 2023 Jan 18:2023.01.16.524266. doi: 10.1101/2023.01.16.524266.

DOI:10.1101/2023.01.16.524266
PMID:36712085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9882159/
Abstract

Sleep deprivation (SD) results in profound cellular and molecular changes in the adult mammalian brain. Some of these changes may result in, or aggravate, brain disease. However, little is known about how SD impacts gene expression in developing animals. We examined the transcriptional response in the prefrontal cortex (PFC) to SD across postnatal development in male mice. We used RNA sequencing to identify functional gene categories that were specifically impacted by SD. We find that SD has dramatically different effects on PFC genes depending on developmental age. Gene expression differences after SD fall into 3 categories: present at all ages (conserved), present when mature sleep homeostasis is first emerging, and those unique to certain ages in adults. Developmentally conserved gene expression was limited to a few functional categories, including Wnt-signaling which suggests that this pathway is a core mechanism regulated by sleep. In younger ages, genes primarily related to growth and development are affected while changes in genes related to metabolism are specific to the effect of SD in adults.

摘要

睡眠剥夺（SD）会导致成年哺乳动物大脑发生深刻的细胞和分子变化。其中一些变化可能会引发或加重脑部疾病。然而，关于SD如何影响发育中动物的基因表达，我们却知之甚少。我们研究了雄性小鼠出生后发育过程中前额叶皮质（PFC）对SD的转录反应。我们使用RNA测序来确定受SD特异性影响的功能基因类别。我们发现，根据发育年龄的不同，SD对PFC基因有着截然不同的影响。SD后的基因表达差异分为3类：在所有年龄段均存在（保守型）、在成熟睡眠稳态首次出现时存在，以及在成年特定年龄段特有的那些。发育保守的基因表达仅限于少数功能类别，包括Wnt信号通路，这表明该通路是受睡眠调节的核心机制。在较年轻的年龄段，主要与生长和发育相关的基因受到影响，而与代谢相关的基因变化则是SD对成年动物影响所特有的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e6/9882159/1ca94c9e8df8/nihpp-2023.01.16.524266v1-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e6/9882159/b6690b5c56ad/nihpp-2023.01.16.524266v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e6/9882159/fec214b0c0da/nihpp-2023.01.16.524266v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e6/9882159/c2e3f6a50619/nihpp-2023.01.16.524266v1-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e6/9882159/dc2ff3ab87f4/nihpp-2023.01.16.524266v1-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e6/9882159/4809d2d25de7/nihpp-2023.01.16.524266v1-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e6/9882159/1e4290dab20a/nihpp-2023.01.16.524266v1-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e6/9882159/1ca94c9e8df8/nihpp-2023.01.16.524266v1-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e6/9882159/b6690b5c56ad/nihpp-2023.01.16.524266v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e6/9882159/fec214b0c0da/nihpp-2023.01.16.524266v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e6/9882159/c2e3f6a50619/nihpp-2023.01.16.524266v1-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e6/9882159/dc2ff3ab87f4/nihpp-2023.01.16.524266v1-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e6/9882159/4809d2d25de7/nihpp-2023.01.16.524266v1-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e6/9882159/1e4290dab20a/nihpp-2023.01.16.524266v1-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e6/9882159/1ca94c9e8df8/nihpp-2023.01.16.524266v1-f0007.jpg

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本文引用的文献

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Increased interaction between endoplasmic reticulum and mitochondria following sleep deprivation.睡眠剥夺后内质网和线粒体之间相互作用增加。
BMC Biol. 2023 Jan 4;21(1):1. doi: 10.1186/s12915-022-01498-7.
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Loss of sleep when it is needed most - Consequences of persistent developmental sleep disruption: A scoping review of rodent models.在最需要睡眠的时候失眠——持续性发育性睡眠中断的后果：对啮齿动物模型的综述
Neurobiol Sleep Circadian Rhythms. 2022 Dec 6;14:100085. doi: 10.1016/j.nbscr.2022.100085. eCollection 2023 May.
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Shank3 influences mammalian sleep development.
Shank3 影响哺乳动物的睡眠发育。
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Early life sleep disruption potentiates lasting sex-specific changes in behavior in genetically vulnerable Shank3 heterozygous autism model mice.早期生活中的睡眠中断会使 Shank3 杂合子自闭症模型小鼠中存在遗传易感性的行为产生持久的性别特异性变化。
Mol Autism. 2022 Aug 29;13(1):35. doi: 10.1186/s13229-022-00514-5.
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Gene Expression Changes of Murine Cortex Homeostasis in Response to Sleep Deprivation Hint Dysregulated Aging-like Transcriptional Responses.小鼠皮层稳态对睡眠剥夺的基因表达变化提示转录反应失调，类似衰老。
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REM sleep promotes bidirectional plasticity in developing visual cortex .快速眼动睡眠促进发育中的视觉皮层的双向可塑性。
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Early life sleep disruption alters glutamate and dendritic spines in prefrontal cortex and impairs cognitive flexibility in prairie voles.早年睡眠中断会改变草原田鼠前额叶皮质中的谷氨酸和树突棘，并损害其认知灵活性。
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