Saad Ahmed S, Ismail Nahla S, Gaber Noran S, Elzanfaly Eman S
Analytical Chemistry Department, Cairo University, Faculty of Pharmacy Kasr El-Aini St 11562 Cairo Egypt
Medicinal Chemistry Department, PharmD Program, Egypt - Japan University of Science and Technology (E-JUST) New Borg El-Arab City 21934 Alexandria Egypt.
RSC Adv. 2023 Jan 11;13(3):1995-2003. doi: 10.1039/d2ra06839g. eCollection 2023 Jan 6.
The use of electrochemical sensors offers a simple, affordable solution with great reliability. Magnesium is a mineral that the body requires to function properly. It encourages preserving a stable pulse, strong bones, and healthy blood pressure. Herein, a novel ion-selective electrode using esomeprazole magnesium trihydrate as an ion-association complex was developed for magnesium(ii) ion determination in mineral water, drug substances, and pharmaceutical formulations. The electrode response was optimized in terms of plasticizer type, ion exchanger concentration, and membrane composition. To find the best sensor combination, the initial optimization research was performed using eight different sensors. A membrane containing 20% esomeprazole magnesium trihydrate, 36% carbon, and 44% -Nitrophenyl Octyl Ether (NPOE) as a plasticizer yielded the best potentiometric response. The developed sensor demonstrated a Nernstian response with a slope of 29.93 ± 0.1 mV per decade in the concentration range of 1.41 × 10 mol L to 1 × 10 mol L. Within a pH range of 5-8, it had a low detection limit of 4.13 × 10 mol L. When compared to the official method, there are no statistically significant differences.
电化学传感器的使用提供了一种简单、经济且可靠性高的解决方案。镁是人体正常运作所需的一种矿物质。它有助于维持稳定的脉搏、强健的骨骼和健康的血压。在此，开发了一种以三水合埃索美拉唑镁作为离子缔合物的新型离子选择性电极，用于测定矿泉水中的镁离子（II）、原料药和药物制剂。在增塑剂类型、离子交换剂浓度和膜组成方面对电极响应进行了优化。为了找到最佳的传感器组合，使用八种不同的传感器进行了初步优化研究。含有20%三水合埃索美拉唑镁、36%碳和44% -硝基苯基辛醚（NPOE）作为增塑剂的膜产生了最佳的电位响应。所开发的传感器在1.41×10⁻⁶ mol/L至1×10⁻² mol/L的浓度范围内表现出能斯特响应，斜率为每十倍浓度变化29.93±0.1 mV。在pH值为5 - 8的范围内，其检测限低至4.13×10⁻⁷ mol/L。与官方方法相比，没有统计学上的显著差异。
