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非移植环境下急性淋巴细胞白血病患者的巨细胞病毒再激活

Cytomegalovirus Reactivation in Patients With Acute Lymphoblastic Leukemia in Non-transplant Setting.

作者信息

Abbas Mansoor, Bin Naeem Sameen, Jhatial Mussadique Ali, Bokhari Syed W, Ahsan Bushra, Ahmad Usman

机构信息

Medical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.

出版信息

Cureus. 2022 Dec 25;14(12):e32936. doi: 10.7759/cureus.32936. eCollection 2022 Dec.

DOI:10.7759/cureus.32936
PMID:36712765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9873483/
Abstract

Acute lymphoblastic leukemia is predominately a childhood disease and around two third of cases are of B-cell phenotype. Cytomegalovirus is an important cause of morbidity and mortality in allogeneic hematopoietic progenitor cell transplant; however, it is rare in patients with B-cell acute lymphoblastic leukemia in non-transplant settings. In this study, we evaluated 72 patients of acute precursor (pre) B-cell acute lymphoblastic leukemia at Shaukat Khanum Memorial Cancer Hospital and Research Center, out of which three were positive for Cytomegalovirus.

摘要

急性淋巴细胞白血病主要是一种儿童疾病，约三分之二的病例为B细胞表型。巨细胞病毒是异基因造血祖细胞移植中发病和死亡的重要原因；然而，在非移植环境下的B细胞急性淋巴细胞白血病患者中却很少见。在本研究中，我们评估了在沙卡特汗姆纪念癌症医院和研究中心的72例急性前体（pre）B细胞急性淋巴细胞白血病患者，其中3例巨细胞病毒呈阳性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5cb/9873483/337d1a390d43/cureus-0014-00000032936-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5cb/9873483/337d1a390d43/cureus-0014-00000032936-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5cb/9873483/337d1a390d43/cureus-0014-00000032936-i01.jpg

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Pediatric-inspired protocols in adult acute lymphoblastic leukemia: are the results bearing fruit?
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