Lu Xuehui, Zhang Guihua, Cen Lingping, Du Yali, Liu Lifang, Jin Chuang, Chen Haoyu
Joint Shantou International Eye Center, Shantou University & the Chinese University of Hong Kong, Shantou 515041, Guangdong, China.
J Ophthalmol. 2023 Jan 20;2023:1504834. doi: 10.1155/2023/1504834. eCollection 2023.
The aim of this study was to analyze choroidal vascular density alteration in high myopia with or without choroidal neovascularization by using optical coherence tomography angiography (OCTA).
This was a cross-sectional, observational study that included 60 high-myopia eyes. All the participants had comprehensive ophthalmic assessments with visual acuity, intraocular pressure, slit lamp-assisted biomicroscopy, color fundus photography, axial length, optometry, and OCTA. Age, sex, and comorbidities were collected from their medical charts. Univariate and multiple analyses were made to compare the age, spherical equivalent, choroidal vascular density, gender, and choroidal thickness between normal and patients with choroidal neovascularization.
60 eyes with high myopia were included in our study, including 30 eyes with choroidal neovascularization and 30 eyes without choroidal neovascularization or other fundus pathology. The mean age of high myopic patients was older in the choroidal neovascularization group than in the normal group (48.43 ± 19.06 years vs. 28.83 ± 9.92 years, < 0.01). The mean choroidal thickness of high myopic patients was thinner in the neovascularization group than in the normal group (68.81 ± 48.81 m vs. 137.80 ± 66.33 m, < 0.01). The mean choroidal vascular density in the normal group was greater than in the choroidal neovascularization group (82.43 ± 8.73 vs. 67.54 ± 12.56, < 0.01). There was no significant difference in spherical equivalent between the choroidal neovascularization group and the normal group (-10.56 ± 2.97D vs. -11.93 ± 3.38D, = 0.11). Multivariate analysis showed that after adjusting for covariates, less choroidal vascular density and older age were independent factors associated with choroidal neovascularization in the high myopic eye.
Decreased choroidal vascular density and older age played an important role in the development of choroidal neovascularization in high myopic eyes. OCTA may help us to identify the highly myopic patients that need to intervene.
本研究旨在通过光学相干断层扫描血管造影（OCTA）分析伴有或不伴有脉络膜新生血管的高度近视患者脉络膜血管密度的变化。
这是一项横断面观察性研究，纳入了60只高度近视眼睛。所有参与者均接受了全面的眼科评估，包括视力、眼压、裂隙灯辅助生物显微镜检查、彩色眼底照相、眼轴长度、验光和OCTA。从他们的病历中收集年龄、性别和合并症信息。进行单因素和多因素分析，以比较正常组和脉络膜新生血管患者组之间的年龄、等效球镜、脉络膜血管密度、性别和脉络膜厚度。
本研究纳入了60只高度近视眼睛，其中30只伴有脉络膜新生血管，30只不伴有脉络膜新生血管或其他眼底病变。脉络膜新生血管组高度近视患者的平均年龄高于正常组（48.43±19.06岁 vs. 28.83±9.92岁，P<0.01）。脉络膜新生血管组高度近视患者的平均脉络膜厚度低于正常组（68.81±48.81μm vs. 137.80±66.33μm，P<0.01）。正常组的平均脉络膜血管密度大于脉络膜新生血管组（82.43±8.73 vs. 67.54±12.56，P<0.01）。脉络膜新生血管组和正常组之间的等效球镜无显著差异（-10.56±2.97D vs. -11.93±3.38D，P=0.11）。多因素分析显示，在调整协变量后，脉络膜血管密度降低和年龄较大是高度近视眼中与脉络膜新生血管相关的独立因素。
脉络膜血管密度降低和年龄较大在高度近视性脉络膜新生血管的发生中起重要作用。OCTA可能有助于我们识别需要干预的高度近视患者。
