Bond Life Sciences Center, University of Missouri, Columbia, MO, United States.
Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Missouri, Columbia, MO, United States.
Front Immunol. 2023 Jan 12;13:1094278. doi: 10.3389/fimmu.2022.1094278. eCollection 2022.
Sjögren's syndrome is a chronic inflammatory autoimmune disease characterized by diminished secretory function of the exocrine glands. Although extensive investigation has been done to understand Sjögren's syndrome, the causes of the disease are as yet unknown and treatments remain largely ineffective, with established therapeutic interventions being limited to use of saliva substitutes with modest effectiveness. A primary feature of Sjögren's syndrome is uncontrolled inflammation of exocrine tissues and previous studies have demonstrated that lipid-based specialized pro-resolving mediators reduce inflammation and restores tissue integrity in salivary glands. However, these studies are limited to a single specialized pro-resolving lipid mediator's family member resolvin D1 or RvD1 and its aspirin-triggered epimer, AT-RvD1. Consequently, additional studies are needed to explore the potential benefits of other members of the specialized pro-resolving lipid mediator's family and related molecules (, additional resolvin subtypes as well as lipoxins, maresins and protectins). In support of this goal, the current review aims to briefly describe the range of current experimental methods to investigate the impact of specialized pro-resolving lipid mediators on Sjögren's syndrome, including both strengths and weaknesses of each approach where this information is known. With this article, the possibilities presented by specialized pro-resolving lipid mediators will be introduced to a wider audience in immunology and practical advice is given to researchers who may wish to take up this work.
干燥综合征是一种慢性炎症性自身免疫性疾病，其特征是外分泌腺的分泌功能减退。尽管已经进行了广泛的研究来了解干燥综合征，但该病的病因尚不清楚，治疗方法仍然基本无效，已确立的治疗干预措施仅限于使用效果有限的唾液替代品。干燥综合征的一个主要特征是外分泌组织的失控炎症，先前的研究表明，基于脂质的专门促解决介质可减少炎症并恢复唾液腺的组织完整性。然而，这些研究仅限于单一的专门促解决脂质介质家族成员解析素 D1 或 RvD1 及其阿司匹林触发的差向异构体 AT-RvD1。因此，需要进行更多的研究来探索专门促解决脂质介质家族和相关分子（其他解析素亚型以及脂氧素、maresins 和保护素）的其他成员的潜在益处。为了支持这一目标，本综述旨在简要描述目前用于研究专门促解决脂质介质对干燥综合征影响的一系列实验方法，包括在已知信息的情况下，每种方法的优缺点。通过本文，将向免疫学领域的更广泛受众介绍专门促解决脂质介质带来的可能性，并为可能希望开展这项工作的研究人员提供实用建议。
